Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

313 questions · 352 findings · 23 reviews · Drugs and Alcohol

No studies found 16 · 4.5%GRADE not reported 34 · 9.7%Very low 113 · 32.1%Low 117 · 33.2%Moderate 57 · 16.2%High 15 · 4.3%

Brief intervention vs treatment

Decreased alcohol use · concurrent problem alcohol and illicit drug users

Brief intervention (BI) showed no clear difference in decreased alcohol use compared with treatment (low certainty).

2 findings from 1 review

Brief intervention vs treatment

Number of drinks per week · concurrent problem alcohol and illicit drug users
2 findings from 1 review

Valproate vs placebo or no intervention

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether valproate changes benzodiazepine discontinuation, end of intervention compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Paroxetine vs placebo or no intervention

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether paroxetine changes benzodiazepine discontinuation, end of intervention compared with placebo or no intervention (very low certainty).

1 finding from 1 review