Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

267 questions · 280 findings · 47 reviews

No studies found 80 · 28.6%GRADE not reported 11 · 3.9%Very low 96 · 34.3%Low 50 · 17.9%Moderate 40 · 14.3%High 3 · 1.1%

Additional support vs usual care

Death of a baby (stillbirth or neonatal death) report of perinatal death · women at increased risk of low birthweight babies (maternal outcomes)

Additional support showed no clear difference in stillbirth/neonatal death compared with usual care during pregnancy (low certainty).

1 finding from 1 review

Additional support vs usual care

Number of antenatal hospital admissions · women at increased risk of low birthweight babies (maternal outcomes)

Additional support probably leads to lower antenatal hospital admissions Number of admissions per woman compared with usual care during pregnancy (moderate certainty).

2 findings from 1 review

Additional support vs usual care

Postnatal depression · women at increased risk of low birthweight babies (maternal outcomes)

Additional support showed no clear difference in postnatal depression Self‐reported compared with usual care during pregnancy (low certainty).

2 findings from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Thiazolidinediones Diagnostic criteria: 2 trials applied the WHO 1999 criteria (FPG ≥ 7.0 mmol/L and/or a 2‐hour glucose ≥ 11.1 mmol/L after a 75 g OGTT) (Jin 2009; Zeng 2013). No medical association recommended the cut‐off points applied in Maji ... · people at increased risk for developing type 2 diabetes

Summary of findings table for metformin showed no clear difference in thiazolidinediones Diagnostic criteria: 2 trials applied the WHO… compared with diet and exercise or another antidiabetic drug (low certainty).

1 finding from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Intensive diet plus exercise · people at increased risk for developing type 2 diabetes
4 findings from 1 review
Show 1 more finding

Metformin vs diet and exercise or another antidiabetic drug

Acarbose · people at increased risk for developing type 2 diabetes
3 findings from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Thiazolidinediones · people at increased risk for developing type 2 diabetes
2 findings from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Placebo or diet and exercise · people at increased risk for developing type 2 diabetes
2 findings from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Placebo or diet and exercise Description: SF‐36 to evaluate the health utility index SF‐6D (physical component summaries and mental component summaries) Minimal important difference: difference in scores between groups of at least 3% · people at increased risk for developing type 2 diabetes
1 finding from 1 review

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

Development of type 2 diabetes · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings table for metformin plus intensive diet and… changes incidence of type 2 diabetes mellitus (N) Diagnostic criteria: 2… compared with intensive diet and exercise (very low certainty).

1 finding from 1 review