Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

720 questions · 751 findings · 105 reviews

No studies found 193 · 25.7%GRADE not reported 37 · 4.9%Very low 212 · 28.2%Low 193 · 25.7%Moderate 99 · 13.2%High 17 · 2.3%

Intralesional steroid injection plus adjunctive treatment vs steroid injection

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Intralesional steroid injection plus adjunctive treatment showed no clear difference in maximal mouth opening (interincisal distance) compared with intralesional steroid injection alone (low certainty).

2 findings from 1 review

Transarterial embolisation plus percutaneous alcohol injection vs percutaneous alcohol injection

Mortality at maximal · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether transarterial embolisation plus percutaneous alcohol injection changes mortality at maximal compared with percutaneous alcohol injection (very low certainty).

1 finding from 1 review

Transarterial embolisation plus percutaneous alcohol injection vs percutaneous alcohol injection

Cancer‐related mortality at maximal · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether transarterial embolisation plus percutaneous alcohol injection changes cancer‐related mortality at maximal compared with percutaneous alcohol injection (very low certainty).

1 finding from 1 review

Transarterial embolisation plus percutaneous alcohol injection vs percutaneous alcohol injection

Serious adverse events (number of participants) · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether transarterial embolisation plus percutaneous alcohol injection changes serious adverse events (number of participants) compared with percutaneous alcohol injection (very low certainty).

1 finding from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Severe postpartum haemorrhage · pregnant women giving birth in non‐facility settings

It is very uncertain whether prophylactic oxytocin injection (delivered by community health… changes severe postpartum haemorrhage (> 1000 mL) [ compared with control (no injection) (very low certainty).

1 finding from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Postpartum haemorrhage · pregnant women giving birth in non‐facility settings

Prophylactic oxytocin injection (delivered by community health… may leads to lower postpartum haemorrhage (PPH greater or equal to 500 mL) [ compared with control (no injection) (low certainty).

2 findings from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Maternal transfer or referral to a health facility · pregnant women giving birth in non‐facility settings

Prophylactic oxytocin injection (delivered by community health… showed no clear difference in transfer or referral to health facility [ compared with control (no injection) (low certainty).

1 finding from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Stillbirth · pregnant women giving birth in non‐facility settings

Prophylactic oxytocin injection (delivered by community health… showed no clear difference in stillbirths [ compared with control (no injection) (low certainty).

1 finding from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Early infant death (0‐3 days) [ · pregnant women giving birth in non‐facility settings

Prophylactic oxytocin injection (delivered by community health… showed no clear difference in early infant death (0‐3 days) [ compared with control (no injection) (low certainty).

1 finding from 1 review