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Evidence found and GRADE certainty

84 questions · 84 findings · 13 reviews · Headline outcomes only

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No studies found 16 · 19%GRADE not reported 2 · 2.4%Very low 20 · 23.8%Low 22 · 26.2%Moderate 18 · 21.4%High 6 · 7.1%

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Recovery during intervention defined as WHZ > 0 in 1 study; 100% weight for height in 1 study · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose… may leads to higher recovery during intervention defined as WHZ > 0 in 1 study; 100%… compared with as a supplement to the usual diet (low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Relapse during intervention defined as admission to inpatient therapeutic care or recurrence of oedema or systematic infections during the study period, and dropouts during intervention period · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose… may leads to lower relapse during intervention defined as admission to inpatient… compared with as a supplement to the usual diet (low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Mortality during intervention · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…

It is very uncertain whether standard ready‐to‐use therapeutic food (RUTF) provided at a dose… changes mortality during intervention compared with as a supplement to the usual diet (very low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…
1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs RUTF using an alternative formulation

Recovery during intervention defined as weight gain ≥ 15% in relation to baseline weight, absence of complications and oedema, and MUAC > 110 mm in 2 studies; MUAC > 12.4 cm without oedema in 1 study; WHZ ≥ 80% for two consecutive visits in 1 stud... · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

Standard ready‐to‐use therapeutic food (RUTF) showed no clear difference in recovery during intervention defined as weight gain ≥ 15% in… compared with RUTF using an alternative formulation (high certainty).

1 finding from 1 review