Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

606 questions · 682 findings · 77 reviews

No studies found 99 · 14.5%GRADE not reported 215 · 31.5%Very low 197 · 28.9%Low 102 · 15%Moderate 48 · 7%High 21 · 3.1%

Prenatal passive tobacco exposure (maternal smoking during pregnancy / in the womb) vs No passive tobacco exposure (non-exposed children)

Dental caries in permanent teeth · Children and adolescents with permanent dentition

No eligible studies examined prenatal tobacco exposure and caries in permanent dentition.

1 finding from 1 review

Prenatal passive tobacco exposure (maternal smoking during pregnancy / in the womb) vs No passive tobacco exposure (non-exposed children)

Caries presence in primary teeth · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)

Prenatal (in-womb) tobacco exposure is associated with higher odds of caries in primary dentition (pooled OR 1.46, 95% CI 1.41 to 1.52; 4 studies; no heterogeneity); certainty not graded.

1 finding from 1 review

Passive tobacco exposure (prenatal maternal smoking or postnatal secondhand/household smoke) vs No passive tobacco exposure (non-exposed children)

Dental caries · Children and adolescents (general population, aged under 20 years)

In children and adolescents, passive tobacco exposure (prenatal or postnatal) is associated with higher odds of dental caries (pooled OR 1.53, 95% CI 1.39 to 1.68; 21 studies), though heterogeneity was high (I2=86.5%); certainty of evidence not graded.

1 finding from 1 review

Secondary (passive/secondhand) smoking exposure during childhood vs No secondary smoking exposure

Caries prevalence (early childhood caries) · Preschool children aged <=71 months (caries outcome assessed at 3-6 years)

Preschool children exposed to secondary smoking have higher odds of caries prevalence (OR 1.77), but the cross-sectional evidence is very uncertain (very low certainty).

2 findings from 1 review

Secondary (passive/secondhand) smoking exposure during childhood vs No secondary smoking exposure

Early childhood caries (ECC) - incidence/risk · Preschool children aged <=71 months (caries outcome assessed at 3-6 years)

Children exposed to secondary smoking from infancy have a higher incidence of early childhood caries by age 3 (RR 1.45; low certainty).

1 finding from 1 review

Epilepsy (as exposure/condition) vs Healthy participants without epilepsy (control group)

Caries in primary teeth: dmft (3 years) · Children and adolescents with epilepsy

In children/adolescents, the dmft (primary teeth) index does not differ significantly with epilepsy (SMD 0.132, 95% CI -0.220 to 0.484, P = .463; ungraded subgroup).

1 finding from 1 review

Epilepsy (as exposure/condition) vs Healthy participants without epilepsy (control group)

Mean DMFT (decayed, missing, filled permanent teeth) · Children and adolescents with epilepsy

In children/adolescents, the higher DMFT with epilepsy is not statistically significant (SMD 0.334, 95% CI -0.140 to 0.827, P = .164; ungraded subgroup).

1 finding from 1 review

Epilepsy (as exposure/condition) vs Healthy participants without epilepsy (control group)

Mean DMFT (decayed, missing, filled permanent teeth) · people with epilepsy

People with epilepsy have a significantly higher DMFT (permanent-teeth caries) index than controls (SMD 0.403, 95% CI 0.057 to 0.749; high certainty).

1 finding from 1 review

Epilepsy (as exposure/condition) vs Healthy participants without epilepsy (control group)

Mean DMFT (decayed, missing, filled permanent teeth) · Adults with epilepsy

In adults, epilepsy is associated with a significantly higher DMFT than controls (SMD 0.548, P < .001; ungraded subgroup analysis).

1 finding from 1 review

Epilepsy (as exposure/condition) vs Healthy participants without epilepsy (control group)

Caries in primary teeth: dmft (3 years) · people with epilepsy

The dmft (primary-teeth caries) index does not differ significantly between people with epilepsy and controls (SMD 0.132, 95% CI -0.22 to 0.484; high certainty).

1 finding from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Number of participants referred for surgical exposure of the PDC · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

It is very uncertain whether double primary (canine and first molar) tooth extraction changes number of participants referred for surgical exposure of the PDC compared with single primary (canine) tooth extraction (very low certainty).

1 finding from 1 review