What do systematic reviews say?

Radiosurgery alone vs WBRT and radiosurgery

• Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  High

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs oral antibiotics

It is very uncertain whether summary of findings table ‐ Combined mechanical and oral antibiotic… changes surgical site infections compared with oral antibiotics alone (very low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.87 [0.34, 2.21]
  3 studies · 960 participants
  Very low

Topical prophylaxis vs no topical prophylaxis

Topical prophylaxis showed no clear difference in respiratory tract infections ‐ topical plus systemic prophylaxis… compared with no topical prophylaxis (low certainty).

• Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical… 2021 · Cochrane Headline outcomes only
  RR 0.82 [0.58, 1.16]
  6 studies · 850 participants
  Low

Sclerotherapy plus compression vs sclerotherapy (any sclerosant)

• Treatment for telangiectasias and reticular veins 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 196 participants
  Moderate

Parachlorometaxylenol with iodine vs iodine alone

It is very uncertain whether parachlorometaxylenol with iodine changes surgical site infection compared with iodine alone (very low certainty).

• Skin preparation for preventing infection following caesarean section 2020 · Cochrane Headline outcomes only
  RR 0.33 [0.04, 2.99]
  1 study · 50 participants
  Very low

Preoperative radiotherapy vs surgery

Preoperative radiotherapy showed no clear difference in overall mortality ‐ only total mesorectal excision ( compared with surgery alone (low certainty).

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  Peto OR 0.97 [0.87, 1.08]
  2 studies · 3211 participants
  Low

Preoperative radiotherapy vs surgery

Preoperative radiotherapy showed no clear difference in curative resection ( compared with surgery alone (low certainty).

• Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
  RR 1 [0.97, 1.02]
  4 studies · 4673 participants
  Low

Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone

It is very uncertain whether autologous platelet concentrates (APC) + enamel matrix derivative… changes change in radiographic bone defect filling (RBF) (%) compared with EMD (enamel matrix derivative) alone (very low certainty).

• Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes

  All follow-ups
  MD -0.60 [-6.21, 5.01]
  1 study · 49 participants
  Very low

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in radiographic bone defect filling (RBF) (%) compared with OFD (open flap debridement) alone (very low certainty).

• Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes

  9 to 12 months
  MD 34.26 [30.07, 38.46]
  9 studies · 401 participants
  Very low

Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone

The review found no eligible studies for this question.

• Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes

  All follow-ups
  No RBF (radiographic bone defect filling) data were available for the APC + GTR versus GTR comparison.
  0 studies
  No studies found

Rituximab (B cell) + steroid vs steroids

Rituximab (B cell) + steroid showed no clear difference in failure of reversal of acute rejection compared with steroid alone (moderate certainty).

• Polyclonal and monoclonal antibodies for treating acute rejection episodes in kidney transplant recipients 2017 · Cochrane Headline outcomes only
  RR 0.94 [0.54, 1.64]
  2 studies · 53 participants
  Moderate

Antibody (T cell) + steroid vs steroids

Antibody (T cell) + steroid showed no clear difference in failure of reversal of acute rejection episode compared with steroid alone (low certainty).

• Polyclonal and monoclonal antibodies for treating acute rejection episodes in kidney transplant recipients 2017 · Cochrane Headline outcomes only
  RR 0.42 [0.17, 1.01]
  1 study · 30 participants
  Low

Antibody (T cell) + steroid vs steroids

Antibody (T cell) + steroid showed no clear difference in recurrent rejection compared with steroid alone (low certainty).

• Polyclonal and monoclonal antibodies for treating acute rejection episodes in kidney transplant recipients 2017 · Cochrane Headline outcomes only
  RR 0.07 [0, 1.06]
  1 study · 30 participants
  Low

Oestrogen therapy alone vs no treatment or placebo

The review found no eligible studies for this question.

• Oestrogen therapy for treating pelvic organ prolapse in postmenopausal women 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oestrogen therapy alone vs pelvic floor muscle training (PFMT)

The review found no eligible studies for this question.

• Oestrogen therapy for treating pelvic organ prolapse in postmenopausal women 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oestrogen therapy alone vs pelvic floor muscle training (PFMT)

The review found no eligible studies for this question.

• Oestrogen therapy for treating pelvic organ prolapse in postmenopausal women 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oestrogen therapy alone vs devices such

The review found no eligible studies for this question.

• Oestrogen therapy for treating pelvic organ prolapse in postmenopausal women 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oestrogen therapy alone vs devices such

The review found no eligible studies for this question.

• Oestrogen therapy for treating pelvic organ prolapse in postmenopausal women 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oestrogen therapy alone vs devices such

The review found no eligible studies for this question.

• Oestrogen therapy for treating pelvic organ prolapse in postmenopausal women 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oestrogen therapy alone vs surgery

The review found no eligible studies for this question.

• Oestrogen therapy for treating pelvic organ prolapse in postmenopausal women 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found