Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

135 questions · 145 findings · 44 reviews · Acute Respiratory Infections

No studies found 10 · 6.9%GRADE not reported 18 · 12.4%Very low 21 · 14.5%Low 54 · 37.2%Moderate 28 · 19.3%High 14 · 9.7%

Antibiotics vs placebo compared

Relapse · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze

Antibiotic therapy showed no clear difference in relapse (children who were 'cured' but developed symptoms within… compared with placebo compared to placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo compared

Adverse effects of antibiotics · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze

Antibiotic therapy showed no clear difference in treatment harms (adverse events or side effects associated with… compared with placebo compared to placebo (low certainty).

1 finding from 1 review

Vitamin C vs placebo

Incidence of pneumonia Defined as patient admitted to hospital with a diagnosis of pneumonia Dose: 2 g per day · school‐aged children (6 to 15 years) and marine corps recruits (mean age 18.5 years)

It is very uncertain whether vitamin C changes incidence of pneumonia Defined as patient admitted to hospital with… compared with placebo (very low certainty).

1 finding from 1 review

Vitamin C vs placebo

Adverse effects (urticaria) Defined as participants reporting urticaria (hives) Dose: 2 g per day · school‐aged children (6 to 15 years) and marine corps recruits (mean age 18.5 years)

It is very uncertain whether vitamin C changes adverse effects (urticaria) Defined as participants reporting… compared with placebo (very low certainty).

1 finding from 1 review

Corticosteroids vs no corticosteroid use

All‐cause mortality Up to 28 days following admission · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number of deaths at 30 days following admission (30‐day mortality)a compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review

Provider‐ or system‐based interventions vs no intervention or another intervention

Reminder (to hospital staff to vaccinate patient) compared to reminder letter to GP on day of discharge · people aged 60 years and older living in the community

Provider‐ or system‐based interventions showed no clear difference in reminder (to hospital staff to vaccinate patient) compared to… compared with no intervention or another intervention (high certainty).

1 finding from 1 review