Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

175 questions · 177 findings · 31 reviews

No studies found 18 · 10.2%GRADE not reported 33 · 18.6%Very low 50 · 28.2%Low 57 · 32.2%Moderate 19 · 10.7%High 0 · 0%

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Episode frequency associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
    Studies not reported
    GRADE not reported

Patient‐initiated appointment systems vs consultant‐led appointment systems

Cost of service utilisation · adults with a chronic or recurrent condition

It is very uncertain whether patient‐initiated appointment systems changes service utilisation (costs) per patient per year compared with consultant‐led appointment systems (very low certainty).

1 finding from 1 review

Intervention not reported

Post‐traumatic stress disorder Score Scale: Clinician Administered PTSD Scale, Posttraumatic Stress Symptoms— Interview, Posttraumatic Stress Disorder Checklist Direction: lower better · women aged 16 years and older who self‐report previous or current experience of intimate partner violence
1 finding from 1 review

Intervention not reported

Antibiotic prescriptions (number of courses/person/year) **Corticosteroids not meta‐analysed · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention may leads to higher antibiotic prescriptions (number of courses/person/year)… (low certainty).

1 finding from 1 review

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ pre‐ and postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Hostility BPRS hostility sub scale, CPRS hostility subscale, Q‐sort, speech content analysis (endpoints fall between 1 and 6 months) · Any individual experiencing recurrent aggressive outbursts or episodes
1 finding from 1 review

Intervention not reported

Anger‐Hostility POMS anger‐hostility subscale (endpoints fall between 1 and 6 months) · Any individual experiencing recurrent aggressive outbursts or episodes
1 finding from 1 review

Intervention not reported

Achievement of at least 50% reduction in headache severity Post‐treatment Higher scores indicate more children with reduced headache · children or adolescents with headaches

It is very uncertain whether the intervention changes achievement of at least 50% reduction in headache severity… (very low certainty).

1 finding from 1 review