Cochrane · systematic review · CD003499
Antiepileptics for aggression and associated impulsivity
Huband, N, Ferriter, M, Nathan, R, et al. · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 3 · 42.9%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: Any individual experiencing recurrent aggressive outbursts or episodes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Aggression OAS, OAS‐M, MOAS, self‐reported incidents, CPRS subscale (endpoints fall between 2 weeks and 6 months) | no estimate extracted | 12 studies · 606 participants | Moderate Downgraded: indirectness |
Impulsivity Q‐sort, Porteus Maze Test (endpoints fall between 2 weeks and 6 months) | no estimate extracted | 2 studies · 43 participants | Very low Downgraded: indirectness |
Hostility BPRS hostility sub scale, CPRS hostility subscale, Q‐sort, speech content analysis (endpoints fall between 1 and 6 months) | no estimate extracted | 4 studies · 143 participants | Low Downgraded: indirectness |
Anger Self‐reported outbursts, Rosenweig Picture Frustration Test (endpoints fall between 2 weeks and 6 months) | no estimate extracted | 2 studies · 46 participants | Low Downgraded: indirectness |
Anger‐Hostility POMS anger‐hostility subscale (endpoints fall between 1 and 6 months) | no estimate extracted | 3 studies · 125 participants | Low Downgraded: indirectness |
Non‐compliance leaving the study early (endpoints fall between 1 and 6 months) | no estimate extracted | 6 studies · 411 participants | Moderate Downgraded: indirectness |
Adverse events, any (endpoints fall between 1 6 six months) | no estimate extracted | 3 studies · 300 participants | Moderate Downgraded: indirectness |