Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

88 questions · 88 findings · 14 reviews

No studies found 17 · 19.3%GRADE not reported 26 · 29.5%Very low 19 · 21.6%Low 9 · 10.2%Moderate 16 · 18.2%High 1 · 1.1%

Dexamethasone vs betamethasone – child outcomes

Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth

Dexamethasone showed no clear difference in any known death after randomisation (fetal, neonatal, child, child… compared with betamethasone – fetal/neonatal outcomes (moderate certainty).

1 finding from 1 review

Oral immunosuppressants: oral cyclosporin vs topical betamethasone dipropionate

Primary: investigator‐rated good/excellent control of symptoms · people with hand eczema, continuously for 6 months, significant disability, inadequate response to conventional treatment, confirmation by…

Oral immunosuppressants: oral cyclosporin showed no clear difference in primary: investigator‐ rated good/excellent control of symptomsb compared with topical betamethasone dipropionate (moderate certainty).

1 finding from 1 review

Oral immunosuppressants: oral cyclosporin vs topical betamethasone dipropionate

Primary: participant‐rated good/excellent control of symptoms · people with hand eczema, continuously for 6 months, significant disability, inadequate response to conventional treatment, confirmation by…

Oral immunosuppressants: oral cyclosporin showed no clear difference in primary: participant‐rated good/excellent control of symptomsb compared with topical betamethasone dipropionate (moderate certainty).

1 finding from 1 review

Oral immunosuppressants: oral cyclosporin vs topical betamethasone dipropionate

Number of participants with any adverse event (primary tolerability outcome) · people with hand eczema, continuously for 6 months, significant disability, inadequate response to conventional treatment, confirmation by…

Oral immunosuppressants: oral cyclosporin showed no clear difference in primary: adverse events ‐ at least 1 adverse event compared with topical betamethasone dipropionate (moderate certainty).

1 finding from 1 review

Ambroxol vs corticosteroid (betamethasone)

Perinatal mortality frequency of deaths of newborns · women at risk of preterm birth

Ambroxol showed no clear difference in perinatal mortality frequency of deaths of newborns compared with corticosteroid (betamethasone) (moderate certainty).

1 finding from 1 review

Ambroxol vs corticosteroid (betamethasone)

Adverse effects in pregnant women frequency in pregnant women · women at risk of preterm birth

It is very uncertain whether ambroxol changes adverse effects in pregnant women frequency in pregnant women compared with corticosteroid (betamethasone) (very low certainty).

1 finding from 1 review

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Complications (adverse effects) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate showed no clear difference in complications (adverse effects) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review