What do systematic reviews say?

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  Use of rescue analgesia recorded in 7 studies; only 2 reported counts (Tuncer 2014: 2 participants; Bruno 2011: 6 participants); no class/dose/timing reported; not pooled. SoF cell: 'Not reported'.
  7 studies
  GRADE not reported

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported this outcome.
  0 studies
  No studies found

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported any adverse events. SoF cell: 'Not reported'.
  0 studies
  No studies found

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies reported this outcome.
  0 studies
  No studies found

Any method, procedure or policy to reduce contaminated aerosols in dental clinics vs Any other method, no treatment or combination of methods

The review found no eligible studies for this question.

• Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
  Reduction in volume of contaminated aerosols in the operative environment: Not reported (row present in all Summary of findings tables)
  0 studies
  No studies found

Any method, procedure or policy to reduce contaminated aerosols in dental clinics vs Any other method, no treatment or combination of methods

The review found no eligible studies for this question.

• Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
  Rate of infection of dental staff or patients: Not reported (row present in all Summary of findings tables)
  0 studies
  No studies found

Root canal medications and canal filling, splinting, extraction of teeth, or surgical removal of any relevant pathology vs Each other, placebo, or no treatment

The review found no eligible studies for this question.

• Interventions for the management of external root resorption 2015 · Cochrane All outcomes

  Any follow-up period
  None of the studies fulfilled our inclusion criteria and therefore no data analysis was conducted. (Main results: no RCTs that met the inclusion criteria were identified; one ongoing study, NCT00423956, potentially…
  0 studies
  No studies found

Consumption of xylitol chewing gum by women (mothers) vs Consumption of CHX/xylitol gum by women, or CHX varnish applied to women's dentition

Consumption of xylitol chewing gum by women (mothers) led to lower child microbiological presence (any mutans streptococci colonisation) compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to…; GRADE not reported.

• Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
  RR 0.60 [0.45, 0.81]
  2 studies
  GRADE not reported

Package of oral health education/promotion including oral hygiene advice for pregnant women, mothers, infants and young children, plus dietary and feeding practice advice for infants and young children vs usual care

Package of oral health education/promotion including oral hygiene… led to lower child plaque (any plaque visible on any teeth) compared with standard care; GRADE not reported.

• Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
  RR 0.35 [0.26, 0.47]
  1 study · 441 participants
  GRADE not reported

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

The review found no eligible studies for this question.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes
  Only root resorption was assessed; other adverse effects (gingival disease, demineralisation) were not reported.
  0 studies
  No studies found

Any orthodontic and/or surgical treatment for Angle Class III malocclusion vs no intervention or another intervention

The review found no eligible studies for this question.

• Treatments for adults with prominent lower front teeth 2012 · Cochrane All outcomes
  No included study measured the planned primary outcome. Discussion: 'The primary outcome proposed for this review was to evaluate the effectiveness of treatments for prognathism, but none of the studies conclusively…
  Studies not reported
  No studies found

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

The review found no eligible studies for this question.

• Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease… 2019 · Cochrane All outcomes
  This outcome was not reported in either of the trials.
  0 studies
  No studies found

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

The review found no eligible studies for this question.

• Antibacterial agents in composite restorations for the prevention of dental caries 2013 · Cochrane All outcomes
  No studies were included in this review, as we were unable to find any trials directly comparing antibacterial containing composites to other active interventions or controls.
  0 studies
  No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes

  To 6 months
  Baysan 2003 stated that no adverse events were reported to 6 months; no information was provided by Abu-Naba'a 2003 or Abu-Naba'a 2003pilot.
  1 study
  GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
  Abu-Naba'a 2003 reported participants' state of anxiety, comparing ozone treatment with traditional dental interventions (injection, drilling, filling); because no participant was randomised between ozone and drilling…
  1 study
  GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

The review found no eligible studies for this question.

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
  Data were not provided by any study on the number of lesions requiring restorations to 6 months or later; no data on any further conventional treatment or other dental interventions.
  Studies not reported
  No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

The review found no eligible studies for this question.

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
  No data were provided in any of the included trials on costs.
  Studies not reported
  No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

The review found no eligible studies for this question.

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
  No data were provided in any of the included trials on pain.
  Studies not reported
  No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes

  6 and 12 months
  No consistent trend of benefit or harm following ozone was seen across the outcome measures in any of the three studies; analyses were conducted at the lesion level (not independent of the person), so data were not…
  3 studies · 137 participants
  GRADE not reported

Horizontal bone augmentation (any technique) vs No augmentation

The review found no eligible studies for this question.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  At least to abutment connection (planned)
  No trial evaluated whether horizontal bone augmentation is necessary (explicit gap)
  0 studies
  No studies found