Ear pain (otalgia) or discomfort or local irritation · people (of any age) with CSOM
It is very uncertain whether systemic antibiotics changes ear pain (otalgia) or discomfort or local irritation ‐ measured at 1… compared with no treatment or placebo on top of topical antibiotics (very low certainty).
1 finding from 1 review
Hearing · people (of any age) with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serious complications ‐ measured at 19 to 24 days · people (of any age) with CSOM
1 finding from 1 review
Suspected ototoxicity · people (of any age) with CSOM
It is very uncertain whether systemic antibiotics changes suspected ototoxicity ‐ measured at 10 days to 3 weeks compared with no treatment or placebo on top of topical antibiotics (very low certainty).
1 finding from 1 review
Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with CSOM
Systemic antibiotics showed no clear difference in resolution of ear discharge ‐ measured at 1 to 2 weeks compared with no treatment or placebo on top of topical antibiotics (low certainty).
1 finding from 1 review
Resolution of ear discharge ‐ measured after 4 weeks · people (of any age) with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Fever ‐ not measured · Women undergoing operative vaginal delivery
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Length of maternal hospital stay (days) · Women undergoing operative vaginal delivery
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Infected episiotomy/laceration (superficial perineal wound infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery
Any antibiotics leads to lower infected episiotomy/laceration (superficial perineal wound… compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.53 [0.4, 0.69]
Studies not reported
High
Infected episiotomy/laceration (deep perineal wound infection № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery
Any antibiotics leads to lower infected episiotomy/laceration (deep perineal wound infection № of… compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.46 [0.31, 0.69]
Studies not reported
High
Infected episiotomy/laceration (organ or space infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery
Any antibiotics showed no clear difference in infected episiotomy/laceration (organ or space infection) № of… compared with placebo or no treatment (low certainty).
1 finding from 1 review
RR 0.11 [0.01, 2.05]
Studies not reported
Low
Infected episiotomy/laceration (wound breakdown) № of participants: 2593 (1 RCT) · Women undergoing operative vaginal delivery
Any antibiotics probably leads to lower infected episiotomy/laceration (wound breakdown) № of participants:… compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 0.52 [0.43, 0.63]
Studies not reported
Moderate
Endometritis · Women undergoing operative vaginal delivery
Any antibiotics showed no clear difference in endometritis № of participants: 3813 (2 RCTs) compared with placebo or no treatment (low certainty).
1 finding from 1 review
RR 0.32 [0.04, 2.64]
Studies not reported
Low
Urinary tract infection ‐ not measured · Women undergoing operative vaginal delivery
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serious infectious complications · Women undergoing operative vaginal delivery
Any antibiotics leads to lower serious infectious complications № of participants: 3420 (1 RCT) compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.44 [0.22, 0.89]
Studies not reported
High
Maternal adverse reactions · Women undergoing operative vaginal delivery
Any antibiotics showed no clear difference in maternal adverse reactions № of participants: 2593 (1 RCT) compared with placebo or no treatment (low certainty).
1 finding from 1 review
RR 2 [0.18, 22.05]
Studies not reported
Low
High prolactin at any time during treatment · people with psychosis
1 finding from 1 review
Adverse effect: any ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
1 finding from 1 review
Health‐related quality of life · people (of any age) with chronic suppurative otitis media or ear discharge
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Ear pain (otalgia) or discomfort or local irritation · people (of any age) with chronic suppurative otitis media or ear discharge
It is very uncertain whether topical antibiotics with steroids changes ear pain (otalgia) or discomfort or local irritation compared with topical antibiotics alone (same antibiotics) (very low certainty).
1 finding from 1 review