Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

143 questions · 144 findings · 18 reviews · Headline outcomes only

No studies found 8 · 5.6%GRADE not reported 1 · 0.7%Very low 32 · 22.2%Low 65 · 45.1%Moderate 32 · 22.2%High 6 · 4.2%

Intervention not reported

Antibody production: number of participants developing IgG antibodies · adults and children with mucopolysaccharidosis I

It is very uncertain whether the intervention changes antibody production: number of participants developing IgG antibodies (very low certainty).

1 finding from 1 review

Two doses of HPV vaccine vs three doses of HPV vaccine

Antibody response (immunogenicity) · 9‐ to 15‐year‐old females

Two doses of HPV vaccine probably leads to lower antibody response (immunogenicity) compared with three doses of HPV vaccine (moderate certainty).

1 finding from 1 review

Mycophenolate mofetil vs azathioprine (AZA)

Acute rejection, steroid resistant/antibody treated As reported in the articles · patients with kidney transplant recipients

Mycophenolate mofetil (MMF) leads to lower acute rejection, steroid resistant/antibody treated As reported in… compared with azathioprine (AZA) (high certainty).

1 finding from 1 review

Red blood cell transfusion vs no transfusion

Erythrocyte alloantibody formation Laboratory assessment · women with postpartum iron deficiency anaemia

It is very uncertain whether red blood cell transfusion changes erythrocyte alloantibody formation Laboratory assessment compared with non‐transfusion (Comparison 2) (very low certainty).

1 finding from 1 review

Immunologic response to YF vaccine in HIV‐infected adults before HIV diagnosis, vs immunologic response to YF vaccine

Immunogenicity: Adequate antibody response (NT ≥1:10), · adults with HIV infection

Immunologic response to YF vaccine in HIV‐infected adults before HIV… may leads to lower immunogenicity: Adequate antibody response (NT ≥1:10), compared with immunologic response to YF vaccine (low certainty).

1 finding from 1 review

Immunologic response to YF vaccine in HIV‐infected children vs immunologic response to YF vaccine

Immunogenicity: Adequate antibody response (NT ≥1:10), · Children with HIV infection

It is very uncertain whether immunologic response to YF vaccine in HIV‐infected children changes adequate antibody response (NT ≥1:10), compared with immunologic response to YF vaccine (very low certainty).

1 finding from 1 review

Immunologic response to YF vaccine in HIV‐infected adults vs immunologic response to YF vaccine

Immunogenicity: Adequate antibody response (NT ≥1:10), · adults with HIV infection

It is very uncertain whether immunologic response to YF vaccine in HIV‐infected adults changes immunogenicity: Adequate antibody response (NT ≥1:10), compared with immunologic response to YF vaccine (very low certainty).

1 finding from 1 review

Immunologic response to YF vaccine in HIV‐infected adults vs immunologic response to YF vaccine

Duration: Adequate antibody response (NT ≥1:10), · adults with HIV infection

It is very uncertain whether immunologic response to YF vaccine in HIV‐infected adults changes duration: Adequate antibody response (NT ≥1:10), compared with immunologic response to YF vaccine (very low certainty).

1 finding from 1 review

Interleukin‐2 RA induction vs monoclonal antibody induction

Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients

Interleukin‐2 RA induction showed no clear difference in acute rejection Acute rejection grade 3A or more verified by biopsy compared with monoclonal antibody induction (low certainty).

1 finding from 1 review

Interleukin‐2 RA induction vs monoclonal antibody induction

Infection Number of participants diagnosed with infection · heart transplant recipients

Interleukin‐2 RA induction showed no clear difference in infection Number of participants diagnosed with infection compared with monoclonal antibody induction (low certainty).

1 finding from 1 review