Cochrane · systematic review · CD007746
Mycophenolic acid versus azathioprine as primary immunosuppression for kidney transplant recipients
Wagner, M, Earley, AK, Webster, AC, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 1 · 14.3%Moderate 1 · 14.3%High 4 · 57.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Mycophenolate mofetil (MMF) versus azathioprine (AZA) for primary immunosuppression in kidney transplant recipients
Population: patients with kidney transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death, all cause Mycophenolate mofetil (MMF) vs azathioprine (AZA) | RR 0.95 [0.7, 1.29] | 16 studies · 2987 participants | Moderate Downgraded: imprecision |
Graft loss, censored for death Mycophenolate mofetil (MMF) vs azathioprine (AZA) | RR 0.78 [0.61, 0.98] | 17 studies · 2540 participants | High |
Malignancy, any Mycophenolate mofetil (MMF) vs azathioprine (AZA) | RR 0.81 [0.6, 1.09] | 5 studies · 1735 participants | Very low Downgraded: imprecision |
Acute rejection, steroid resistant/antibody treated As reported in the articles Mycophenolate mofetil (MMF) vs azathioprine (AZA) | RR 0.48 [0.36, 0.65] | 15 studies · 2914 participants | High |
Infection, CMV tissue invasive As reported in the articles Mycophenolate mofetil (MMF) vs azathioprine (AZA) | RR 1.7 [1.1, 2.61] | 7 studies · 1510 participants | High |
Acute rejection, total Any treated acute rejection, including biopsy‐proven Mycophenolate mofetil (MMF) vs azathioprine (AZA) | RR 0.65 [0.57, 0.73] | 22 studies · 3301 participants | High |
Chronic allograft nephropathy Biopsy required in 2 RCTs, one study with optional biopsy Mycophenolate mofetil (MMF) vs azathioprine (AZA) | RR 0.69 [0.48, 0.99] | 3 studies · 203 participants | Low Downgraded: imprecision |