Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

86 questions · 97 findings · 12 reviews

No studies found 14 · 14.4%GRADE not reported 4 · 4.1%Very low 31 · 32%Low 29 · 29.9%Moderate 15 · 15.5%High 4 · 4.1%

Endovascular therapy plus conventional medical treatment vs medical treatment

Death or stroke · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in 30‐day post‐randomisation death/stroke compared with medical treatment alone (low certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs medical treatment

Fatal/non‐fatal stroke in the territory of the treated vertebral artery stenosis(assessed after 30 days post‐randomisation to completion of · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in fatal/non‐fatal stroke in the territory of the treated vertebral… compared with medical treatment alone (moderate certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs medical treatment

Stroke (ischaemic or haemorrhagic)Median · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in stroke (ischaemic or haemorrhagic)Median compared with medical treatment alone (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants who experienced operative or postoperative serious adverse events · patients with multiple sclerosis and chronic cerebrospinal venous insufficiency (CCSVI)

The intervention showed no clear difference in proportion of participants who experienced operative or… (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants who experienced improvement of composite functional endpoint over 12 months · patients with multiple sclerosis and chronic cerebrospinal venous insufficiency (CCSVI)

The intervention showed no clear difference in proportion of participants who experienced improvement of composite… (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants who experienced new relapses over 12 months · patients with multiple sclerosis and chronic cerebrospinal venous insufficiency (CCSVI)

The intervention showed no clear difference in proportion of participants who experienced new relapses over 12 months (moderate certainty).

1 finding from 1 review

PTA vs stent

Technical success · people with infrapopliteal arterial lesions in chronic limb‐threatening ischaemia

PTA probably leads to higher technical success ITT No. of limbs: 476 (5 RCTs) compared with stent (moderate certainty).

2 findings from 1 review

PTA vs stent

Procedural complications · people with infrapopliteal arterial lesions in chronic limb‐threatening ischaemia

PTA showed no clear difference in procedural complications ITT No. of participants: 360 (5 RCTs) compared with stent (moderate certainty).

2 findings from 1 review

PTA vs stent

Primary patency ( · people with infrapopliteal arterial lesions in chronic limb‐threatening ischaemia

PTA showed no clear difference in primary patency < 6 months ITT No. of lesions: 456 (3 RCTs) compared with stent (moderate certainty).

2 findings from 1 review