Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

97 questions · 97 findings · 11 reviews

No studies found 45 · 46.4%GRADE not reported 6 · 6.2%Very low 4 · 4.1%Low 21 · 21.6%Moderate 14 · 14.4%High 7 · 7.2%

Probenecid vs allopurinol

Acute gout attacks · people with chronic gout

Probenecid showed no clear difference in acute gout attacks compared with allopurinol (low certainty).

1 finding from 1 review

Probenecid vs allopurinol

Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Benzbromarone vs allopurinol

Serum urate normalisation ‐ not reported · people with chronic gout

Benzbromarone showed no clear difference in serum urate normalisation compared with allopurinol (moderate certainty).

1 finding from 1 review

Benzbromarone vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Benzbromarone showed no clear difference in withdrawal due to adverse events compared with allopurinol (low certainty).

1 finding from 1 review

Febuxostat 40 mg/day vs allopurinol

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 40 mg/day showed no clear difference in serum uric acid <6.0 mg/dL at final visit compared with allopurinol (moderate certainty).

1 finding from 1 review