Febuxostat 40 mg/day vs allopurinol: Acute gout attacks
Febuxostat 40 mg/day showed no clear difference in incidence of gout flares compared with allopurinol (high certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Febuxostat 40 mg/day vs allopurinol Incidence of gout flares · patients with chronic gout Febuxostat 40 mg/day showed no clear difference in incidence of gout flares compared with allopurinol (high certainty). Febuxostat for treating chronic gout (2012) · Cochrane Headline outcomes only | RR 0.97 [0.57, 1.65] | 1 study · 1324 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Febuxostat for treating chronic gout 2012 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.