What do systematic reviews say?

Intervention not reported

The review found no eligible studies for this question.

• Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent postoperative pain… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The intervention showed no clear difference in intraoperative pain (reported dichotomous) (low certainty).

• Use of hyaluronidase as an adjunct to local anaesthetic eye blocks to reduce intraoperative pain in adults 2018 · Cochrane Headline outcomes only
  RR 0.83 [0.48, 1.42]
  4 studies · 289 participants
  Low

Intervention not reported

• Use of hyaluronidase as an adjunct to local anaesthetic eye blocks to reduce intraoperative pain in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 211 participants
  Low

Intervention not reported

• Use of hyaluronidase as an adjunct to local anaesthetic eye blocks to reduce intraoperative pain in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Intervention not reported

• Use of hyaluronidase as an adjunct to local anaesthetic eye blocks to reduce intraoperative pain in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 122 participants
  Moderate

Intervention not reported

• Use of hyaluronidase as an adjunct to local anaesthetic eye blocks to reduce intraoperative pain in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 141 participants
  Moderate

Intervention not reported

• Use of hyaluronidase as an adjunct to local anaesthetic eye blocks to reduce intraoperative pain in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Active cerebral oxygenation monitoring vs blinded cerebral oxygenation monitoring

• Cerebral near‐infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 312 participants
  Low

Active cerebral oxygenation monitoring vs blinded cerebral oxygenation monitoring

Active cerebral oxygenation monitoring showed no clear difference in postoperative stroke ( compared with blinded cerebral oxygenation monitoring (low certainty).

• Cerebral near‐infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults 2018 · Cochrane Headline outcomes only
  RR 0.25 [0.03, 2.2]
  2 studies · 240 participants
  Low

Active cerebral oxygenation monitoring vs blinded cerebral oxygenation monitoring

Active cerebral oxygenation monitoring showed no clear difference in POD: postoperative delirium ( compared with blinded cerebral oxygenation monitoring (low certainty).

• Cerebral near‐infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults 2018 · Cochrane Headline outcomes only
  RR 0.63 [0.27, 1.45]
  1 study · 190 participants
  Low

Active cerebral oxygenation monitoring vs blinded cerebral oxygenation monitoring

Active cerebral oxygenation monitoring may leads to lower POCD defined by original studies ‐ mild ( compared with blinded cerebral oxygenation monitoring (low certainty).

• Cerebral near‐infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults 2018 · Cochrane Headline outcomes only
  RR 0.53 [0.3, 0.95]
  2 studies · 126 participants
  Low

Active cerebral oxygenation monitoring vs blinded cerebral oxygenation monitoring

Active cerebral oxygenation monitoring showed no clear difference in POCD: decline in cognitive function ( compared with blinded cerebral oxygenation monitoring (moderate certainty).

• Cerebral near‐infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults 2018 · Cochrane Headline outcomes only
  RR 0.62 [0.37, 1.04]
  6 studies · 962 participants
  Moderate

Active cerebral oxygenation monitoring vs blinded cerebral oxygenation monitoring

Active cerebral oxygenation monitoring showed no clear difference in intraoperative mortality or postoperative mortality: Death ( compared with blinded cerebral oxygenation monitoring (low certainty).

• Cerebral near‐infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults 2018 · Cochrane Headline outcomes only
  RR 0.63 [0.08, 5.03]
  3 studies · 390 participants
  Low

Active cerebral oxygenation monitoring vs blinded cerebral oxygenation monitoring

The review found no eligible studies for this question.

• Cerebral near‐infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low tidal volume vs high tidal volume

Low tidal volume showed no clear difference in mortality compared with high tidal volume (low certainty).

• Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
  RR 0.8 [0.42, 1.53]
  12 studies · 1207 participants
  Low

Low tidal volume vs high tidal volume

Low tidal volume probably leads to lower pneumonia compared with high tidal volume (moderate certainty).

• Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
  RR 0.45 [0.25, 0.82]
  7 studies · 778 participants
  Moderate

Low tidal volume vs high tidal volume

Low tidal volume probably leads to lower need for postoperative non‐invasive ventilatory support compared with high tidal volume (moderate certainty).

• Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
  RR 0.31 [0.15, 0.64]
  3 studies · 506 participants
  Moderate

Low tidal volume vs high tidal volume

Low tidal volume probably leads to lower need for postoperative invasive ventilatory support compared with high tidal volume (moderate certainty).

• Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
  RR 0.33 [0.14, 0.77]
  11 studies · 957 participants
  Moderate

Low tidal volume vs high tidal volume

• Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 898 participants
  Low

Low tidal volume vs high tidal volume

• Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  14 studies · 1298 participants
  Low