Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
1 finding from 1 review
Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Induction chemotherapy plus locoregional treatment (radiotherapy… led to lower locoregional control, induction cisplatin + 5-fluorouracil +… compared with locoregional treatment (radiotherapy and/or surgery) alone; GRADE not reported.
1 finding from 1 review
RR 0.80 [0.64, 0.99]
3 studies
GRADE not reported
Size of the lower jaw (arch length, change) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Schwarz appliance showed no clear difference in size of the lower jaw (mandibular arch length, change) at 9 months compared with no active treatment (control); GRADE not reported.
1 finding from 1 review
Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
17 findings from 1 review
Show 14 more findings
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Dentine-caries (D3) prevalence low <15% (non-CBCT)
Sensitivity 0.36 [0.25, 0.47]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Reference standard: excavation (non-CBCT)
Sensitivity 0.51 [0.27, 0.74]
5 studies
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Analogue and digital combined (non-CBCT); 97 datasets
Sensitivity 0.46 [0.40, 0.51]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Dentine-caries (D3) prevalence high >=35% or unreported (non-CBCT)
Sensitivity 0.50 [0.40, 0.59]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Sensitivity analysis: low risk of bias for index test
Sensitivity 0.51 [0.43, 0.61]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Sensitivity analysis: excluding high/unclear risk of bias reference standard
Sensitivity 0.51 [0.45, 0.57]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Setting: in vivo / clinical (non-CBCT)
Sensitivity 0.56 [0.43, 0.69]
17 studies
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Setting: in vitro (non-CBCT)
Sensitivity 0.44 [0.37, 0.50]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Sensitivity analysis: low dentine-caries prevalence <15%
Sensitivity 0.34 [0.25, 0.45]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Reference standard: histology (non-CBCT)
Sensitivity 0.46 [0.39, 0.53]
64 studies
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies)
Sensitivity 0.47 [0.40, 0.53]
77 studies
Low
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Occlusal surfaces (non-CBCT)
Sensitivity 0.45 [0.35, 0.54]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Primary dentition (non-CBCT)
Sensitivity 0.52 [0.40, 0.63]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Proximal surfaces (non-CBCT)
Sensitivity 0.47 [0.39, 0.55]
Studies not reported
GRADE not reported
Sensitivity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
10 findings from 1 review
Show 7 more findings
Changes in vertical height of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
It is very uncertain whether ARP with alloplast plus barrier membrane changes changes in vertical height of alveolar ridge (mm) compared with ARP with alloplast without membrane (very low certainty).
1 finding from 1 review
Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
It is very uncertain whether non-selective carious tissue removal and conventional restoration (CR) changes failure of therapy compared with selective carious tissue removal (selective excavation, SE) (very low certainty).
3 findings from 1 review
Specificity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Aesthetic outcomes of future prosthodontic rehabilitation · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
The review found no eligible studies for this question.
1 finding from 1 review
Outcome not reported
0 studies
No studies found
Incidence of eruption of the PDC into the mouth · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
Double primary (canine and first molar) tooth extraction led to higher incidence of eruption of the PDC into the mouth compared with single primary (canine) tooth extraction; GRADE not reported.
4 findings from 1 review
RR 1.28 [1.06, 1.54]
2 studies · 96 participants
GRADE not reported
RR 0.68 [0.35, 1.31]
3 studies · 119 participants
Very low
RR 0.61 [0.29, 1.25]
1 study · 23 participants
GRADE not reported
Show 1 more finding
Diastolic blood pressure (mmHg), change from baseline · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Periodontal treatment (subgingival SRP with or without other… showed no clear difference in change in diastolic blood pressure (DBP, mmHg) compared with no treatment (no periodontal treatment) (low certainty).
4 findings from 1 review
Show 1 more finding
Harms (toxicity and postoperative sensitivity) · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6 to 12 years)
1 finding from 1 review
SoF (Harms, follow-up 2 weeks to 7 years): See comments; 3 studies; certainty very low (⊕⊝⊝⊝). Comments: data were reported for physical development, neurological and psychological effects, neurobehavioural and…
3 studies
Very low
Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
3 findings from 1 review
Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
It is very uncertain whether nitinol archwire changes amount of crowding (change) up to 37 weeks compared with titinol archwire (very low certainty).
1 finding from 1 review
Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Clinical attachment level (CAL) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Periodontal treatment (subgingival SRP with or without other… led to lower clinical attachment level (CAL) compared with no treatment (no periodontal treatment); GRADE not reported.
1 finding from 1 review
COE with blood/salivary (biomarker) analysis vs Reference standard: examination and clinical evaluation by a physician/clinician with specialist knowledge or training (long-term follow-up accepted for those screened negative)
Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
The review found no eligible studies for this question.
1 finding from 1 review
Specificity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
1 finding from 1 review
Summary of findings 4 (no pooled analysis): specificity 0.99 (95% CI 0.99 to 1.00), 1.00 (95% CI 0.91 to 1.00), and 0.72 (95% CI 0.63 to 0.80) across the 3 studies. Certainty VERY LOW.
3 studies · 3600 participants
Very low
Sensitivity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
2 findings from 1 review
Electrical conductance for the detection of dental caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Permanent dentition
Permanent dentition (4 studies): sensitivity ranged from 0.55 to 0.65.
4 studies
GRADE not reported
Electrical conductance for the detection of dental caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Primary dentition
Primary dentition (3 studies): sensitivity ranged from 0.91 to 0.93. No evidence of a difference in accuracy by dentition (removing accuracy covariate: Chi2=3.15, df=1, P=0.08).
3 studies
GRADE not reported
Time to alignment · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Active self-ligating brackets showed no clear difference in time to alignment (days) compared with passive self-ligating brackets; GRADE not reported.
1 finding from 1 review