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What do systematic reviews say?

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Evidence found and GRADE certainty

1,103 questions · 1,157 findings · 177 reviews · Headline outcomes only

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No studies found 291 · 25.2%GRADE not reported 85 · 7.3%Very low 317 · 27.4%Low 258 · 22.3%Moderate 169 · 14.6%High 37 · 3.2%

Early vs delayed open or laparoscopic appendicectomy

Time away from normal activities (days) · paediatric and adult patients with appendiceal phlegmon

It is very uncertain whether early changes time away from normal activities (days) Median compared with delayed open or laparoscopic appendicectomy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo/open control

Death or dependence (mRS 4 to 6) at day 90 · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Recombinant activated factor VII showed no clear difference in death or dependence (mRS 4–6) compared with placebo/open control (low certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo/open control

All serious adverse events · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Antifibrinolytic drug(s) showed no clear difference in all serious adverse events compared with placebo/open control (high certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo/open control

Death from any cause · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Antifibrinolytic drug(s) showed no clear difference in death from any cause compared with placebo/open control (high certainty).

1 finding from 1 review

Summary of findings table ‐ Platelet transfusion vs open control

Death or dependence (mRS 4 to 6) at day 90 · adults with acute spontaneous intracerebral haemorrhage associated with antiplatelet drug use

Summary of findings table ‐ Platelet transfusion probably leads to higher death or dependence (mRS 4–6) compared with open control (moderate certainty).

1 finding from 1 review