Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Biofeedback plus standard therapy vs sham biofeedback plus standard therapy

Clinical remission or improvement · people with irritable bowel syndrome

It is very uncertain whether biofeedback plus standard therapy changes clinical response (adequate improvement or remission) compared with sham biofeedback plus standard therapy (very low certainty).

1 finding from 1 review

Radiotherapy vs botulinum toxin

Reduction in the amount of saliva production in the short term using an objective measure · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

The review found no eligible studies for this question.

1 finding from 1 review

Radiotherapy vs botulinum toxin

Adverse events, reported as "negative experiences" · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

It is very uncertain whether radiotherapy changes adverse events, reported as "negative experiences" compared with botulinum toxin (very low certainty).

1 finding from 1 review