Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

778 questions · 809 findings · 116 reviews

No studies found 205 · 25.3%GRADE not reported 111 · 13.7%Very low 225 · 27.8%Low 155 · 19.2%Moderate 85 · 10.5%High 28 · 3.5%

Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO

Incidence of fractures
4 findings from 1 review
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Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO

Severe adverse events
4 findings from 1 review
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Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO

Breast cancer mortality: ≤ 50 years

It is very uncertain whether risk‐reducing salpingo‐oophorectomy (RRSO) changes breast cancer mortality: ≤ 50 years compared with no RRSO (very low certainty).

2 findings from 1 review

Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO

Breast cancer mortality: > 50 years

It is very uncertain whether risk‐reducing salpingo‐oophorectomy (RRSO) changes breast cancer mortality: > 50 years compared with no RRSO (very low certainty).

2 findings from 1 review

Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status

Overall survival: BRCA1 only

It is very uncertain whether risk‐reducing salpingo‐oophorectomy (RRSO) changes overall survival: BRCA1 only compared with no RRSO according to BRCA mutation status (very low certainty).

1 finding from 1 review

Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status

Overall survival: BRCA2 only

It is very uncertain whether risk‐reducing salpingo‐oophorectomy (RRSO) changes overall survival: BRCA2 only compared with no RRSO according to BRCA mutation status (very low certainty).

1 finding from 1 review