Findings

What do systematic reviews say?

1,938 questions · 1,994 findings · 246 reviews · Headline outcomes only

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No studies found 490 · 24.6%GRADE not reported 71 · 3.6%Very low 669 · 33.6%Low 446 · 22.4%Moderate 264 · 13.2%High 54 · 2.7%

Coblation vs Different surgical technique (any)

Pain postoperative day 3 № of participants: 401 (5 studies) · patients requiring tonsillectomy (any diagnosis)

1 finding from 1 review

Coblation versus other surgical techniques for tonsillectomy 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Coblation vs Different surgical technique (any)

Pain postoperative day 7 № of participants: 420 (5 studies) · patients requiring tonsillectomy (any diagnosis)

1 finding from 1 review

Coblation versus other surgical techniques for tonsillectomy 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Coblation vs Different surgical technique (any)

Intraoperative blood loss (mL) · patients requiring tonsillectomy (any diagnosis)

1 finding from 1 review

Coblation versus other surgical techniques for tonsillectomy 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Coblation vs Different surgical technique (any)

Primary bleeding № of participants: 2055 (25 studies) · patients requiring tonsillectomy (any diagnosis)

Coblation showed no clear difference in primary bleeding № of participants: 2055 (25 studies) compared with other surgical techniques (low certainty).

1 finding from 1 review

Coblation versus other surgical techniques for tonsillectomy 2017 · Cochrane Headline outcomes only
RR 0.99 [0.48, 2.05]
Studies not reported
Low

Coblation vs Different surgical technique (any)

Secondary bleeding № of participants: 2118 (25 studies) · patients requiring tonsillectomy (any diagnosis)

Coblation showed no clear difference in secondary bleeding № of participants: 2118 (25 studies) compared with other surgical techniques (low certainty).

1 finding from 1 review

Coblation versus other surgical techniques for tonsillectomy 2017 · Cochrane Headline outcomes only
RR 1.36 [0.95, 1.95]
Studies not reported
Low

Summary of findings: liposomal bupivacaine vs placebo

Cumulative pain score from the end of operation (0 hours) to 72 hours (NRS 0 to 10) · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 189 participants
Very low

Summary of findings: liposomal bupivacaine vs bupivacaine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 134 participants
Very low

Summary of findings: liposomal bupivacaine vs bupivacaine

Time to first postoperative opioid dose over initial 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

The review found no eligible studies for this question.

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: liposomal bupivacaine vs bupivacaine

Total postoperative opioid consumption over first 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 134 participants
Very low

Summary of findings: liposomal bupivacaine vs bupivacaine

Percentage of participants not requiring postoperative opioids over initial 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 134 participants
Very low

Summary of findings: liposomal bupivacaine vs bupivacaine

Incidence of adverse events within 30 days of surgery · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 583 participants
Moderate

Summary of findings: liposomal bupivacaine vs placebo

Serious adverse events · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 382 participants
Low

Summary of findings: liposomal bupivacaine vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · aged 18 years and older undergoing elective surgery at any surgical site

The review found no eligible studies for this question.

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: liposomal bupivacaine vs placebo

Time to first postoperative opioid dose over initial 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 382 participants
Low

Summary of findings: liposomal bupivacaine vs placebo

Total postoperative opioid consumption over first 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 189 participants
Very low

Summary of findings: liposomal bupivacaine vs placebo

Percentage of participants not requiring postoperative opioids over initial 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 382 participants
Very low

Summary of findings: liposomal bupivacaine vs placebo

Incidence of adverse events within 30 days of surgery · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 382 participants
Low

Summary of findings: liposomal bupivacaine vs bupivacaine

Cumulative pain score from the end of operation (0 hours) to 72 hours (NRS 0 to 10) · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 379 participants
Very low

Summary of findings: liposomal bupivacaine vs bupivacaine

Serious adverse events · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 583 participants
Moderate

All irrigation vs no irrigation

Surgical site infection · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

All irrigation showed no clear difference in SSI compared with no irrigation (low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 0.87 [0.68, 1.11]
14 studies · 6106 participants
Low