Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,270 questions · 1,480 findings · 174 reviews

No studies found 252 · 17%GRADE not reported 405 · 27.4%Very low 301 · 20.3%Low 284 · 19.2%Moderate 174 · 11.8%High 64 · 4.3%

Procedures: doffing with double gloves vs doffing with single gloves

Contamination: virus detected ‐ face · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes contamination: virus detected ‐ face compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Procedures: doffing with double gloves vs doffing with single gloves

Contamination: virus detected ‐ shirt · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes contamination: virus detected ‐ shirt compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Procedures: doffing with double gloves vs doffing with single gloves

Contamination: virus detected ‐ pants · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes contamination: virus detected ‐ pants compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Procedures: doffing with double gloves vs doffing with single gloves

Compliance with guidance ‐ Noncompliance: any error · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes non‐compliance: any error compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Procedures: doffing with double gloves vs doffing with single gloves

Contamination with fluorescent · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes contamination with fluorescent compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Daily aural toileting vs single aural toileting episode

Frequency of adverse effects ‐ dizziness ( · people (of any age) with otorrhoea for a duration of at least 6 weeks

It is very uncertain whether daily aural toileting changes adverse events: dizziness Assessed by: self reported compared with single aural toileting episode (very low certainty).

1 finding from 1 review

Daily aural toileting vs single aural toileting episode

Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with otorrhoea for a duration of at least 6 weeks

It is very uncertain whether daily aural toileting changes resolution of ear discharge ‐ 1 to 2 weeks Assessed by: unknown ‐… compared with single aural toileting episode (very low certainty).

1 finding from 1 review

Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic

Total number of ibuprofen tablets · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis

Systemic antibiotic (oral penicillin 500 mg) plus analgesic showed no clear difference in total number of ibuprofen tablets compared with placebo plus analgesic (low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Not applicable (single-arm safety outcome)

Serious adverse events · Children and older adults treated with SDF for carious lesions

No serious adverse events (e.g., allergic reactions or toxicity) were reported for SDF across the reviews (ungraded).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Not applicable (single-arm safety outcome)

Adverse events: black staining of arrested lesions · Children and older adults treated with SDF for carious lesions

Black staining of arrested lesions was the main adverse event of SDF (reported by seven reviews); it was generally acceptable to patients (ungraded).

1 finding from 1 review

Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic

Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID)) · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
1 finding from 1 review
  • Antibiotic use for irreversible pulpitis 2019 · Cochrane All outcomes
    7 days
    Corresponding risk (Antibiotics): The in between-group differences (median +/- IQR) in SPID for the penicillin group were 6.0 +/- 10.5, and for placebo 6.0 +/- 9.5. The SPPID for the penicillin group was 3.5 +/- 7.5…
    1 study · 40 participants
    Low