Bacterial sepsis · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation showed no clear difference in bacterial sepsis№ of participants: 3565(8 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 0.86 [0.74, 1]
Studies not reported
Low
Fungal Infection · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation may leads to lower fungal infection№ of participants: 3266(6 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 0.23 [0.1, 0.54]
Studies not reported
Low
Chronic lung disease · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation showed no clear difference in chronic lung disease№ of participants: 2984(5 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 1 [0.89, 1.12]
Studies not reported
Low
Length of hospital stay · prevention of sepsis and necrotizing enterocolitis in preterm infants
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis available] · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation with enteral feeds in combination with… may leads to lower any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis… compared with placebo (low certainty).
1 finding from 1 review
NEC ≥ stage II · prevention of sepsis and necrotizing enterocolitis in preterm infants
It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes NEC ≥ stage II compared with placebo (very low certainty).
1 finding from 1 review
Length (cm) · the promotion of growth and prevention of infections in infants less than six months of age
1 finding from 1 review
Weight (g) after 6 months · the promotion of growth and prevention of infections in infants less than six months of age
1 finding from 1 review
Mean weight‐for‐age z‐score · the promotion of growth and prevention of infections in infants less than six months of age
1 finding from 1 review
Stunting · the promotion of growth and prevention of infections in infants less than six months of age
1 finding from 1 review
Weight‐for‐length/height z‐score at the end of the intervention Weight scale, measurement boards and child growth reference · the promotion of growth and prevention of infections in infants less than six months of age
1 finding from 1 review
Stunted after 6 months · the promotion of growth and prevention of infections in infants less than six months of age
Zinc supplementation showed no clear difference in stunted after 6 months compared with placebo; no treatment (moderate certainty).
1 finding from 1 review
Wasted after 6 months · the promotion of growth and prevention of infections in infants less than six months of age
Zinc supplementation showed no clear difference in wasted after 6 months compared with placebo; no treatment (low certainty).
1 finding from 1 review
Intraventricular haemorrhage · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants
It is very uncertain whether supine midline head position changes intraventricular haemorrhage, any grade compared with any other supine head position (very low certainty).
1 finding from 1 review
Intraventricular haemorrhage, Papile grade 3/4 · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants
It is very uncertain whether supine midline head position changes intraventricular haemorrhage, grade 3 to 4 compared with any other supine head position (very low certainty).
1 finding from 1 review
All‐cause mortality during hospital stay · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants
It is very uncertain whether supine midline head position changes mortality during initial hospitalisation compared with any other supine head position (very low certainty).
1 finding from 1 review
Long‐term neurodevelopmental outcome ‒not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Major neurodevelopmental disability ‒not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cerebellar haemorrhage on brain ultrasound ‐ not reported · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Failure of modality · preventing respiratory failure in preterm infants
It is very uncertain whether diaphragm‐triggered non‐invasive changes failure of modality compared with other non‐invasive respiratory support (very low certainty).
1 finding from 1 review