What do systematic reviews say?

Occlusal intervention as an adjunct to periodontal therapy vs Sham (placebo) occlusal intervention as an adjunct to periodontal therapy

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.01 [-0.20, 0.22]
  1 study · 50 participants
  GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to non-surgical periodontal therapy led to higher clinical attachment level change (mean gain, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.38 [0.04, 0.72]
  1 study · 50 participants
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to lower sites failing to gain 2 mm attachment (proportion) compared with open flap debridement (access flap surgery); GRADE not reported.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes

  >=12 months
  RR 0.54 [0.31, 0.96]
  6 studies
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

The review found no eligible studies for this question.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
  No data were found for this outcome (listed under 'Other outcomes: No data were found for the following outcomes').
  0 studies
  No studies found

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher change in gingival recession compared with open flap debridement (access flap surgery); GRADE not reported.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes

  >=12 months
  MD 0.26 [0.08, 0.43]
  9 studies
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Guided tissue regeneration (GTR) with barrier membrane (resorbable… showed no clear difference in treatment / surgical procedure time compared with open flap debridement (access flap surgery); GRADE not reported.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
  MD 23.9
  1 study
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher change in clinical attachment level (attachment gain) compared with open flap debridement (access flap surgery); GRADE not reported.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes

  >=12 months
  MD 1.22 [0.80, 1.64]
  16 studies
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher hard tissue probing at surgical re-entry (bone gain) compared with open flap debridement (access flap surgery); GRADE not reported.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes

  >=12 months
  MD 1.39 [1.08, 1.71]
  3 studies
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

The review found no eligible studies for this question.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
  No data were found for this outcome (listed under 'Other outcomes: No data were found for the following outcomes').
  0 studies
  No studies found

GTR rm associated with bone substitutes vs Open flap debridement (access flap surgery)

Guided tissue regeneration (GTR) combined with bone substitutes/graft led to higher hard tissue probing at surgical re-entry (bone gain) compared with open flap debridement (access flap surgery); GRADE not reported.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes

  >=12 months
  MD 3.37 [3.14, 3.61]
  1 study
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes

  >=12 months
  Radiographic data was contained in two studies. Mayfield 1998 showed 0.6 mm gain in bone from the base of the defect in both test and control groups; Ratka-Kruger 2000 reported descriptively that only minute changes in…
  2 studies
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
  No tooth loss was reported in any study although these data are incomplete where patient follow-up was not complete (no events; no estimable effect).
  17 studies
  GRADE not reported

GTR rm associated with bone substitutes vs Open flap debridement (access flap surgery)

Guided tissue regeneration (GTR) combined with bone substitutes/graft led to higher change in clinical attachment level (attachment gain) compared with open flap debridement (access flap surgery); GRADE not reported.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes

  >=12 months
  MD 1.25 [0.89, 1.61]
  2 studies
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher change in probing depth (probing depth reduction) compared with open flap debridement (access flap surgery); GRADE not reported.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes

  >=12 months
  MD 1.21 [0.53, 1.88]
  11 studies
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

The review found no eligible studies for this question.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
  No data were found for this outcome (listed under 'Other outcomes: No data were found for the following outcomes').
  0 studies
  No studies found

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

The review found no eligible studies for this question.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
  No data were found for this outcome (listed under 'Other outcomes: No data were found for the following outcomes').
  0 studies
  No studies found

GTR rm associated with bone substitutes vs Open flap debridement (access flap surgery)

Guided tissue regeneration (GTR) combined with bone substitutes/graft led to higher change in probing depth (probing depth reduction) compared with open flap debridement (access flap surgery); GRADE not reported.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes

  >=12 months
  MD 1.24 [0.89, 1.59]
  2 studies
  GRADE not reported

GTR rm associated with bone substitutes vs Open flap debridement (access flap surgery)

Guided tissue regeneration (GTR) combined with bone substitutes/graft led to lower change in gingival recession compared with open flap debridement (access flap surgery); GRADE not reported.

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes

  >=12 months
  MD -0.33 [-0.43, -0.23]
  1 study
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
  Cortellini 2001: 36% of GTR patients reported the procedure interfered with daily activity for an average of 2.7 days versus 32% of controls for an average of 2.4 days; no significant difference for postoperative pain…
  1 study
  GRADE not reported