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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

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No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Stroke · people with or without existing cardiovascular disease, men and women

It is very uncertain whether homocysteine‐lowering interventions (high dose) changes stroke compared with homocysteine‐lowering interventions (low dose) (very low certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ High sodium dialysate vs standard sodium dialysate

Dialysis dysequilibrium syndrome · patients requiring haemodialysis

It is very uncertain whether summary of findings table ‐ High sodium dialysate changes dialysis dysequilibrium syndrome compared with standard sodium dialysate (very low certainty).

1 finding from 1 review

Summary of findings table ‐ High sodium dialysate vs standard sodium dialysate

Severe dialysis dysequilibrium syndrome · patients requiring haemodialysis

It is very uncertain whether summary of findings table ‐ High sodium dialysate changes severe dialysis dysequilibrium syndrome compared with standard sodium dialysate (very low certainty).

1 finding from 1 review

Higher threshold (500 mL per six hours or greater) vs lower threshold (less than 500 mL per six hours) at time of aspiration

Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether higher threshold (500 mL per six hours or greater) changes mortality (at the end of compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).

1 finding from 1 review

Higher threshold (500 mL per six hours or greater) vs lower threshold (less than 500 mL per six hours) at time of aspiration

Pneumonia · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether higher threshold (500 mL per six hours or greater) changes pneumonia (until discontinued or up to 28 days) compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).

1 finding from 1 review

High‐treatment‐dose vitamin D (greater than 1000 IU/day) vs low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day)

Clinical relapse · people with inflammatory bowel disease

High‐treatment‐dose vitamin D (greater than 1000 IU/day) showed no clear difference in clinical relapse at end of study (52 weeks) compared with low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day) (low certainty).

1 finding from 1 review