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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,280 questions in 114 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 37.5%Ungraded 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Inhalation before vs during airway clearance techniques Measures of sputum clearance: sputum wet weight immediately (g) · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | 2 studies · 26 participants | Low |
Inhalation before vs during airway clearance techniques LCI · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 13 participants | Low |
Inhalation before vs during airway clearance techniques Adverse events · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Inhalation before vs after airway clearance techniques FEV1 % predicted · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 50 participants | Low |
Inhalation before vs after airway clearance techniques FVC % predicted · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 50 participants | Low |
Summary of findings: water‐soluble vitamin E vs control Vitamin E total lipid ratio · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control Neuropathy due to vitamin E deficiency · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control Retinopathy due to vitamin E deficiency · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control BMI · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control Height · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control FEV1 % predicted: change from baseline · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control Vitamin E levels in serum: umol/L · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | MD 19.74 [13.48, 26] | 1 study · 45 participants | Low |
Summary of findings: water‐soluble vitamin E vs control Neuropathy due to vitamin E deficiency · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control Retinopathy due to vitamin E deficiency · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control BMI · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control Height · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control FEV1 % predicted: change from baseline · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control Vitamin E total lipid ratio · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control Vitamin E levels in serum: umol/l · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | 6 participants | Ungraded |
Intervention NR FEV1 change from start of treatment (L) · adults and children with cystic fibrosis and P aeruginosa Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis (2020) · Cochrane | no estimate extracted | 2 studies · 68 participants | High |
Intervention NR FEV1 change from start of treatment (% predicted) · adults and children with cystic fibrosis and P aeruginosa Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 34 participants | Moderate |
Intervention NR Time to next exacerbation · adults and children with cystic fibrosis and P aeruginosa Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 39 participants | Moderate |
Intervention NR Adverse events: number of moderate adverse events · adults and children with cystic fibrosis and P aeruginosa Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis (2020) · Cochrane | RR 0.36 [0.07, 1.77] | 2 studies · 73 participants | Moderate |
Intervention NR Sputum density: change in P aeruginosa sputum density (log1₀ CFU/g) · adults and children with cystic fibrosis and P aeruginosa Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis (2020) · Cochrane | no estimate extracted | 2 studies · 70 participants | High |
Intervention NR Quality of life: change in CFQ‐R score from start of treatment · adults and children with cystic fibrosis and P aeruginosa Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis (2020) · Cochrane | no estimate extracted | 1 study · 38 participants | Moderate |
Summary of findings ‐ DVD plus information booklet vs information booklet alone Mood or personal well‐being · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ computerised learning vs no intervention QoL: Canadian Haemophilia Outcomes‐Kids’ Life Assessment Tool (post‐treatment scores) · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | 1 study · 17 participants | Very low |
Summary of findings ‐ computerised learning vs no intervention Compliance or adherence to the trial intervention (including satisfaction) · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | 1 study · 17 participants | Very low |
Summary of findings ‐ computerised learning vs no intervention Physical health · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ computerised learning vs no intervention Cost of psychological intervention · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ computerised learning vs no intervention Family adjustment · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control Mood or personal well‐being: change in distress (according to General Severity Index) · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | 1 study · 24 participants | Very low |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control Coping strategies · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control QoL · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control Compliance or adherence to the trial intervention (including satisfaction for it) · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | 1 study · 24 participants | Very low |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control Physical health: number of bags of blood required, mean factor usage scores · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | 2 studies · 44 participants | Low |
Summary of findings ‐ DVD plus information booklet vs information booklet alone Coping strategies: Pain Stages of Change Questionaire, Haemophilia Pain Coping Questionnaire, Chronic Pain Acceptance Questionnaire · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | 1 study · 108 participants | Low |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control Cost of psychological intervention · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control Family adjustment · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment Mood or personal well‐being · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment Coping strategies · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment QoL · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment Compliance or adherence to the trial intervention, (including satisfaction) · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | 1 study · 7 participants | Very low |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment Physical health: Reduction of bleedings, factor replacement, pain · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | 1 study · 7 participants | Very low |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment Cost of psychological intervention · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment Family adjustment · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ DVD plus information booklet vs information booklet alone QoL: Rand36a questionnaire · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | 1 study · 108 participants | Low |
Summary of findings ‐ DVD plus information booklet vs information booklet alone Compliance or adherence to the trial intervention (including satisfaction): use of intervention at least once · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | RR 1.02 [0.81, 1.28] | 1 study · 108 participants | Low |
Summary of findings ‐ DVD plus information booklet vs information booklet alone Physical health: pain intensity (VAS post‐treatment scores) · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | 1 study · 108 participants | Low |
Summary of findings ‐ DVD plus information booklet vs information booklet alone Cost of psychological intervention · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |