Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,289 questions · 2,331 findings · 195 reviews · Pregnancy and Childbirth

No studies found 480 · 20.6%GRADE not reported 288 · 12.4%Very low 467 · 20%Low 630 · 27%Moderate 338 · 14.5%High 128 · 5.5%

LMWH prophylaxis vs UFH

Adverse effects sufficient to stop treatment · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: LMWH changes adverse effects sufficient to stop treatment compared with UFH (very low certainty).

1 finding from 1 review

Heparin prophylaxis vs no treatment/placebo

Symptomatic thromboembolic events ( · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic thromboembolic events ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Heparin prophylaxis vs no treatment/placebo

Symptomatic PE · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic PE ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Heparin prophylaxis vs no treatment/placebo

Symptomatic DVT · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic DVT ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Heparin prophylaxis vs no treatment/placebo

Adverse effects sufficient to stop treatment · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes adverse effects sufficient to stop treatment compared with no treatment/placebo (very low certainty).

1 finding from 1 review

LMWH prophylaxis vs UFH

Symptomatic thromboembolic events ( · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: LMWH changes symptomatic thromboembolic events ( compared with UFH (very low certainty).

1 finding from 1 review

Antihistamines vs placebo

Nausea · preventing nausea and vomiting

It is very uncertain whether antihistamines changes nausea ‐ intraoperative compared with placebo (very low certainty).

2 findings from 1 review