Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

696 questions · 700 findings · 53 reviews · Anaesthesia

No studies found 107 · 15.3%GRADE not reported 151 · 21.6%Very low 144 · 20.6%Low 178 · 25.4%Moderate 97 · 13.9%High 23 · 3.3%

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine · patients with postoperative pain

Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine, studies with lower risk of bias · patients with postoperative pain

Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Clonidine vs midazolam

Number requiring additional analgesia at any time postoperatively ‐ low dose clonidine · patients with postoperative pain

Clonidine may leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with midazolam (low certainty).

1 finding from 1 review

Clonidine vs midazolam

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine · patients with postoperative pain

Clonidine may leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with midazolam (low certainty).

1 finding from 1 review

Clonidine vs midazolam

Haemodynamic or respiratory changes requiring intervention · patients with postoperative pain

Clonidine probably leads to lower haemodynamic or respiratory changes requiring intervention compared with midazolam (moderate certainty).

1 finding from 1 review

Clonidine vs fentanyl

Additional analgesia required (escape analgesia) · patients with postoperative pain

Clonidine showed no clear difference in number requiring additional analgesia at any time postoperatively compared with fentanyl (moderate certainty).

1 finding from 1 review