Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,429 questions · 3,558 findings · 436 reviews

No studies found 660 · 18.5%GRADE not reported 375 · 10.5%Very low 727 · 20.4%Low 887 · 24.9%Moderate 709 · 19.9%High 200 · 5.6%

Targeted or adjustable individualized fortification vs standard non‐individualized fortification

Bronchopulmonary dysplasia · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted or adjustable individualized fortification changes bronchopulmonary dysplasia compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Perinatal mortality · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher perinatal death (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Neonatal death (death within the first 28 days of life) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher neonatal death before 28 days (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Stillbirth · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher stillbirth (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal infection or inflammation (at population level) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher maternal infection or inflammation (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal death · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids showed no clear difference in maternal mortality (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Intervention not reported

Treatment discontinuation due to adverse event (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention probably leads to lower treatment discontinuation due to adverse event (safety population) (moderate certainty).

1 finding from 1 review

Intervention not reported

Treatment‐related death (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention may leads to higher treatment‐related death (safety population) (low certainty).

1 finding from 1 review

Intervention not reported

Nausea/vomiting* grade 3 or 4 (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention may leads to higher nausea/vomiting* grade 3 or 4 (safety population) (low certainty).

1 finding from 1 review

Intervention not reported

Anaemia grade 3 or 4 (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention may leads to higher anaemia grade 3 or 4 (safety population) (low certainty).

1 finding from 1 review

Intervention not reported

Leukopaenia (safety population) · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention probably leads to higher leukopaenia (safety population) (moderate certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Bronchopulmonary dysplasia · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in bronchopulmonary dysplasia (at 36 to 38 weeks' PMA) compared with control (moderate certainty).

1 finding from 1 review

Incentives vs no incentives

Smoking cessation in mixed populations ‐ Longest · s

Incentives leads to higher smoking cessation in mixed populations ‐ Longest compared with no incentives (high certainty).

1 finding from 1 review