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What do systematic reviews say?

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Evidence found and GRADE certainty

954 questions · 963 findings · 130 reviews · Headline outcomes only

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No studies found 181 · 18.8%GRADE not reported 71 · 7.4%Very low 163 · 16.9%Low 311 · 32.3%Moderate 163 · 16.9%High 74 · 7.7%

Silicone hydrogel vs hydrogel soft contact lenses

Comfort · Adults with refractive errors

The review found no eligible studies for this question.

3 findings from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Proportion of participants who discontinued contact lens wear, at 1 week (RR < 1 favored) · Adults with refractive errors

It is very uncertain whether silicone hydrogel changes proportion of participants who discontinued contact lens wear, at 1… compared with hydrogel soft contact lenses (very low certainty).

1 finding from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Corneal staining scores, at 1 week (MD < 0 favored) · Adults with refractive errors

It is very uncertain whether silicone hydrogel changes corneal staining scores, at 1 week (MD < 0 favored) compared with hydrogel soft contact lenses (very low certainty).

1 finding from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Conjunctival staining scores, at 1 month (MD < 0 favored) · Adults with refractive errors

It is very uncertain whether silicone hydrogel changes conjunctival staining scores, at 1 month (MD < 0 favored) compared with hydrogel soft contact lenses (very low certainty).

1 finding from 1 review

Dexamethasone vs betamethasone – child outcomes

Developmental delay –motor (mild, moderate or severe) · women at risk of preterm birth

Dexamethasone showed no clear difference in developmental delay –motor (mild, moderate or severe) compared with betamethasone – child outcomes (moderate certainty).

1 finding from 1 review

Dexamethasone vs betamethasone – child outcomes

Intellectual impairment: developmental delay – cognitive or language (mild, moderate or severe) · women at risk of preterm birth

Dexamethasone showed no clear difference in intellectual impairment: developmental delay – cognitive or language… compared with betamethasone – child outcomes (moderate certainty).

1 finding from 1 review

Dexamethasone vs betamethasone – maternal outcomes

Maternal adverse effects of therapy · women at risk of preterm birth

Dexamethasone showed no clear difference in maternal adverse effects of therapy compared with betamethasone – maternal outcomes (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Remifentanil vs diazepam

Surgical assessment/satisfaction score = 1 or 2 (Technically successful procedure as defined by trial authors) · health problem or population

Summary of findings table ‐ Remifentanil may leads to higher surgical assessment/satisfaction score = 1 or 2 (Technically… compared with diazepam (low certainty).

1 finding from 1 review

Summary of findings table ‐ Remifentanil vs diazepam

Maternal OAA score (observer assessment of alertness/sedation) < 4 (Maternal sedation measured using sedation scores as defined by authors) · health problem or population

Summary of findings table ‐ Remifentanil may leads to lower maternal OAA score (observer assessment of alertness/sedation) < 4… compared with diazepam (low certainty).

1 finding from 1 review