Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,016 questions · 2,067 findings · 222 reviews · Headline outcomes only

No studies found 471 · 22.8%GRADE not reported 108 · 5.2%Very low 570 · 27.6%Low 458 · 22.2%Moderate 363 · 17.6%High 97 · 4.7%

Antibiotics vs placebo

Prostatitis symptoms: 'responders' Number of participants with a 25% or 6‐point decrease in NIH‐CPSI scores · participants with chronic prostatitis/chronic pelvic pain syndrome

Antibiotic therapy showed no clear difference in prostatitis symptoms: 'responders' Number of participants with a 25%… compared with placebo (low certainty).

1 finding from 1 review

14 days on/off antibiotic regimen vs 14 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

14 days on/off antibiotic regimen probably leads to lower exacerbation frequency compared with 14 days on/off placebo regimen (moderate certainty).

2 findings from 1 review

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Pulmonary exacerbations: number of hospitalisations due to respiratory exacerbations · people with bronchiectasis

28 days on/off antibiotic regimen showed no clear difference in hospitalisation for pulmonary exacerbations compared with 28 days on/off placebo regimen (high certainty).

1 finding from 1 review

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

28 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off placebo regimen (high certainty).

2 findings from 1 review