Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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SUMMARY OF FINDINGS FOR DECOMPRESSION vs medical treatment

Death or severe disability (mRS > 4) at 6 to 12 months · malignant cerebral oedema after ischaemic stroke

Summary of findings table ‐ surgical decompression leads to lower death or severe disability (mRS > 4) at 6 to 12 months compared with medical treatment alone (high certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR DECOMPRESSION vs medical treatment

Death or moderate disability (mRS > 3) at 6 to 12 months · malignant cerebral oedema after ischaemic stroke

Summary of findings table ‐ surgical decompression probably leads to lower death or moderate disability (mRS > 3) at 6 to 12 months compared with medical treatment alone (moderate certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR DECOMPRESSION vs medical treatment

Severe disability (mRS = 5) at 6 to 12 months · malignant cerebral oedema after ischaemic stroke

Summary of findings table ‐ surgical decompression showed no clear difference in severe disability (mRS = 5) at 6 to 12 months compared with medical treatment alone (low certainty).

1 finding from 1 review

Preconception lifestyle advice on a combination of topics vs usual care or attention control

Reported behavioural changes on vitamin or mineral supplement intake: number of women with adequate use of folic acid supplement · people with infertility

Preconception lifestyle advice on a combination of topics showed no clear difference in reported behavioural changes on vitamin or mineral supplement… compared with routine care or attention control (low certainty).

1 finding from 1 review

Preconception lifestyle advice on a combination of topics vs usual care or attention control

Reported behavioural changes in alcohol intake · people with infertility

Preconception lifestyle advice on a combination of topics showed no clear difference in reported behavioural changes in alcohol intake (measured at 6 months) compared with routine care or attention control (low certainty).

1 finding from 1 review