Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Digital technology vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · adolescents and adults with cystic fibrosis

Digital technology showed no clear difference in number of pulmonary exacerbations: number of participants… compared with usual care (moderate certainty).

1 finding from 1 review

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Bronchopulmonary dysplasia · preterm infants receiving nasal CPAP

Bubble showed no clear difference in bronchopulmonary dysplasia compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review

Caffeine vs other methylxanthines

c) Developmental delay more than two SDs below population mean on a standardized test of development: cognitive delay № of participants: 79(1 RCT) · preterm infants

It is very uncertain whether caffeine changes c) Developmental delay more than two SDs below population mean on a… compared with other methylxanthines (very low certainty).

1 finding from 1 review

Caffeine vs other methylxanthines

c) Developmental delay more than two SDs below population mean on a standardized test of development: language delay № of participants: 79(1 RCT) · preterm infants

It is very uncertain whether caffeine changes c) Developmental delay more than two SDs below population mean on a… compared with other methylxanthines (very low certainty).

1 finding from 1 review

Caffeine vs other methylxanthines

c) Developmental delay more than two SDs below population mean on a standardized test of development: motor delay № of participants: 79(1 RCT) · preterm infants

It is very uncertain whether caffeine changes c) Developmental delay more than two SDs below population mean on a… compared with other methylxanthines (very low certainty).

1 finding from 1 review

Stepwise excavation (two-stage caries removal, re-entry after an interval) vs Non-selective or complete carious tissue removal

Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars

Stepwise excavation reduced the reported risk of pulp exposure by 69% versus complete caries removal (RR 0.31; ungraded).

1 finding from 1 review

Selective carious tissue removal (selective excavation, SE) vs Non-selective or complete carious tissue removal

Pulp exposure during caries removal · Children with dentine caries in primary and permanent teeth

Partial caries removal was reported to reduce pulp-exposure risk by 77% versus complete caries removal (RR 0.23; ungraded).

1 finding from 1 review

Selective carious tissue removal (selective excavation, SE) vs Non-selective or complete carious tissue removal

Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars

Partial caries removal reduced the reported risk of pulp exposure versus complete caries removal in primary teeth (RR 0.24; ungraded).

1 finding from 1 review

Dental caries assessment (WHO/clinical diagnostic criteria; caries = DMFT>0) vs None (descriptive prevalence; random-effects pooled proportion)

Dental caries prevalence · Children (deciduous and/or permanent dentition) in low- and middle-income countries

About 39% of children in LMICs had dental caries (pooled prevalence 0.387, 95% CI 0.284 to 0.495; 11 studies; very high heterogeneity I2=99%; not GRADE-rated).

1 finding from 1 review

Summary of findings: colistimethate dry powder for inhalation (Colobreathe®) vs tobramycin

Pulmonary exacerbations · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: colistimethate dry powder for inhalation… showed no clear difference in pulmonary exacerbations: number of pulmonary exacerbations compared with tobramycin (moderate certainty).

1 finding from 1 review