What do systematic reviews say?

Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin

The review found no eligible studies for this question.

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes necrotising enterocolitis, any Bell stage compared with pentoxifylline with antibiotics and immunoglobulin M‐enriched… (very low certainty).

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  RR 1.33 [0.31, 5.66]
  1 study · 102 participants
  Very low

Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin

The review found no eligible studies for this question.

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes all‐cause mortality during hospital stay compared with immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics (very low certainty).

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  RR 1.25 [0.36, 4.39]
  1 study · 102 participants
  Very low

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

The review found no eligible studies for this question.

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

The review found no eligible studies for this question.

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

The review found no eligible studies for this question.

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

The review found no eligible studies for this question.

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes necrotising enterocolitis, any Bell stage compared with immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics (very low certainty).

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  RR 1.33 [0.31, 5.66]
  1 study · 102 participants
  Very low

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

The review found no eligible studies for this question.

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes all‐cause mortality during hospital stay compared with pentoxifylline with antibiotics and immunoglobulin M‐enriched… (very low certainty).

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  RR 0.71 [0.24, 2.1]
  1 study · 102 participants
  Very low

Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin

The review found no eligible studies for this question.

• Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

Antibiotic eardrops (with or without a corticosteroid) probably leads to higher resolution of ear discharge at short‐term compared with oral antibiotics (moderate certainty).

• Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube)… 2016 · Cochrane Headline outcomes only
  RR 2.58 [1.27, 5.22]
  1 study · 42 participants
  Moderate

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

Antibiotic eardrops (with or without a corticosteroid) showed no clear difference in adverse events compared with oral antibiotics (low certainty).

• Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube)… 2016 · Cochrane Headline outcomes only
  RR 0.37 [0.12, 1.09]
  3 studies · 705 participants
  Low

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

• Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube)… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 153 participants
  Very low

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

Antibiotic eardrops (with or without a corticosteroid) probably leads to higher resolution of ear discharge at intermediate‐term compared with oral antibiotics (moderate certainty).

• Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube)… 2016 · Cochrane Headline outcomes only
  RR 1.7 [1.38, 2.08]
  1 study · 153 participants
  Moderate

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

• Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube)… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 232 participants
  Moderate

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

Antibiotic eardrops (with or without a corticosteroid) showed no clear difference in tube blockage compared with oral antibiotics (low certainty).

• Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube)… 2016 · Cochrane Headline outcomes only
  RR 1.2 [0.33, 4.45]
  2 studies · 121 participants
  Low

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

The review found no eligible studies for this question.

• Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube)… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

• Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube)… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 153 participants
  Low