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Evidence found and GRADE certainty

2,262 questions · 2,405 findings · 248 reviews · Headline outcomes only

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No studies found 507 · 21.1%GRADE not reported 93 · 3.9%Very low 657 · 27.3%Low 708 · 29.4%Moderate 387 · 16.1%High 53 · 2.2%

Lay health worker‐ vs enhanced usual care

Functional impairment · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes functional impairment (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Service utilisation ‐ Unplanned hospitalisation in past 12 months (RR > 1 denotes higher risk of hospitalisation) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes service utilisation ‐ Unplanned hospitalisation in past 12 months… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes adverse events ‐ death in past 12 months (RR > 1 denotes higher risk… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Adverse events RR < 1 indicates lower risk of adverse events · adults with common mental disorders

Lay health worker‐led psychological interventions may leads to lower adverse events RR < 1 indicates lower risk of adverse events compared with usual care (low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Prevalence of morphine use · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of morphine use compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes clinical symptoms ‐ alcohol use (< 1 month post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical symptoms ‐ drug use (< 1 month post intervention) ‐ heroin · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes clinical symptoms ‐ drug use (< 1 month post intervention) ‐ heroin compared with enhanced usual care (very low certainty).

1 finding from 1 review