Somnolence · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
It is very uncertain whether benzodiazepines (topical clonazepam) changes adverse effects: drowsiness compared with placebo (very low certainty).
1 finding from 1 review
Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 4, Clinical resolution (not completely resolved) at 3 to 6 months: '3 studies (freeze-dried black raspberry gel, green tea extract capsules, mixed tea) did not find evidence of benefit.' No GRADE. Effects text:…
4 studies
GRADE not reported
Adverse effects: dry mouth · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
It is very uncertain whether benzodiazepines (topical clonazepam) changes adverse effects: dry mouth compared with placebo (very low certainty).
1 finding from 1 review
Intraoperative pain · Children and adolescents aged up to 17 years having dental treatment (orthodontic treatment, fillings, pulp treatment, or tooth…
The review found no eligible studies for this question.
1 finding from 1 review
Nocturnal symptom: nightmares (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)
Oral appliance or functional orthopaedic appliance showed no clear difference in nocturnal symptom: nightmares (questionnaire) compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Alteration of growth pattern (cephalometric data or facial analysis) · Children with obstructive sleep apnoea (aged 15 years or younger)
The review found no eligible studies for this question.
1 finding from 1 review
Postoperative pain (continuous measure: self report using visual analogue scale) · Children and adolescents having orthodontic separator placement (without local anaesthetic)
Preoperative ibuprofen may leads to lower postoperative pain (continuous measure: self report using visual… compared with placebo (low certainty).
1 finding from 1 review
Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia
Systemic beta carotene or carotenoids (incl. lycopene) may leads to lower improvement of histological features (not improved) compared with placebo or no treatment (low certainty).
1 finding from 1 review
Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 6, Histological changes: 'Not measured'. Effects text: data on histological changes from Armstrong 2013 were not available for analysis, but study authors reported no statistically significant differences in…
1 study
GRADE not reported
Adverse effects (narrative) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomesshort-term (up to 3 months)
SoF4. Adverse effects: single study narratively reported 4 participants (20%) in the bethanechol arm experienced adverse events (nausea, dizziness, blood pressure fall, cold perspiration or sporadic abdominal pain);…
1 study · 40 participants
Very low
Adverse events · Children and adolescents having orthodontic separator placement (without local anaesthetic)
1 finding from 1 review
Tiredness · Children with obstructive sleep apnoea (aged 15 years or younger)
It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: tiredness (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Nocturnal symptom: habitual snoring (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)
It is very uncertain whether oral appliance or functional orthopaedic appliance changes nocturnal symptom: habitual snoring (questionnaire) compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Improvement in nutritional intake · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Somnolence · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
It is very uncertain whether anticonvulsants (gabapentin + alpha lipoic acid) changes adverse effects: drowsiness compared with placebo (very low certainty).
1 finding from 1 review
Side effects / tolerability · Children with obstructive sleep apnoea (aged 15 years or younger)
1 finding from 1 review
Tolerability: 73.7% fitted with oral appliance (14/19 children) tolerated the treatment well and 26.3% (five children) discontinued therapy. Side effects: the included study did not assess this outcome.
1 study · 19 participants
GRADE not reported
Change in QoL - anxiety (surrogate marker) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
It is very uncertain whether physical barriers (tongue protector) changes change in QoL - anxiety (surrogate marker) compared with placebo (very low certainty).
1 finding from 1 review
Heart rate, respiratory rate, and blood pressure · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review
Ahuja 1994: no significant difference in heart rate, respiratory rate, and blood pressure between groups. Takmaz 2009: no differences in respiratory rate and blood pressure, but children in the placebo group had…
2 studies
GRADE not reported
Daytime symptom: sleepiness (Brouillette questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)
It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: sleepiness (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Change of the arch perimeter (plaster models) · Children with obstructive sleep apnoea (aged 15 years or younger)
The review found no eligible studies for this question.
1 finding from 1 review