Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,352 questions · 1,400 findings · 169 reviews

No studies found 309 · 22.1%GRADE not reported 115 · 8.2%Very low 350 · 25%Low 324 · 23.1%Moderate 240 · 17.1%High 62 · 4.4%

Summary of findings: monoclonal antibody KB001‐A vs placebo

Need for antibiotics time to need for antibiotics · children (12 or over) and adults with cystic fibrosis and lung infection

Summary of findings: monoclonal antibody KB001‐A showed no clear difference in need for antibiotics time to need for antibiotics compared with placebo (moderate certainty).

1 finding from 1 review

Zinc vs placebo

Pulmonary exacerbations number of participants requiring IV antibiotics · children with cystic fibrosis

Summary of findings: Zinc supplementation showed no clear difference in pulmonary exacerbations number of participants requiring IV… compared with placebo (moderate certainty).

1 finding from 1 review

Zinc vs placebo

Need for antibiotics days of antibiotic use · children with cystic fibrosis

It is very uncertain whether summary of findings: Zinc supplementation changes need for antibiotics number of days on IV or oral antibiotics compared with placebo (very low certainty).

1 finding from 1 review

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Number of participants with symptomatic UTI · primary VUR

Antibiotic prophylaxis showed no clear difference in symptomatic UTI by 1 to 2 years: antibiotics versus no prophylaxis compared with surveillance or no treatment (low certainty).

2 findings from 1 review

Inhaled corticosteroids vs placebo

Respiratory exacerbations: number of days on intravenous antibiotics for respiratory exacerbations · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: inhaled corticosteroids changes respiratory exacerbations: number of days on intravenous antibiotics… compared with placebo (very low certainty).

1 finding from 1 review

Comparison 1: antibiotic alone or antibiotic with other newborn care interventions vs usual care

Neonatal mortality · neonates with sepsis

Comparison 1: antibiotic alone or antibiotic with other newborn care… showed no clear difference in neonatal mortality ‐ antibiotics alone compared with standard care (moderate certainty).

2 findings from 1 review

Comparison 1: route of antibiotic vs usual care

Neonatal mortality ‐ oral + injectable antibiotics · neonates with sepsis

Comparison 1: route of antibiotic showed no clear difference in neonatal mortality ‐ oral + injectable antibiotics compared with standard care (moderate certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs aclidinium alone

Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in exacerbations requiring steroids or antibiotics or both: number of… compared with aclidinium alone (moderate certainty).

1 finding from 1 review