Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,262 questions · 2,405 findings · 248 reviews · Headline outcomes only

No studies found 507 · 21.1%GRADE not reported 93 · 3.9%Very low 657 · 27.3%Low 708 · 29.4%Moderate 387 · 16.1%High 53 · 2.2%

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Prevalence of methamphetamine use (1 to 6 months post intervention) (RR < 1 denotes lower prevalence compared to control) · adult patients with harmful or hazardous alcohol or substance use

Lay health worker‐led interventions for adult patients with harmful… showed no clear difference in prevalence of methamphetamine use (1 to 6 months post intervention)… compared with enhanced usual care (low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) ‐ risk of hazardous or harmful alcohol use · adult patients with harmful or hazardous alcohol or substance use
1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Clinical symptoms ‐ alcohol and substance use (1 to 6 months post intervention) · adult patients with harmful or hazardous alcohol or substance use
1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Functional impairment ‐ not measured · adults with common mental disorders

Lay health worker‐led psychological interventions showed no clear difference in functional impairment/disability ‐ intermediate term (1 to 6 months… compared with usual care (low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Quality of life · adult patients with harmful or hazardous alcohol or substance use

The review found no eligible studies for this question.

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Service utilisation ‐ unplanned hospitalisations (1 to 6 months post intervention) (RR < 1 denotes lower risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes service utilisation ‐ unplanned hospitalisations (1 to 6 months post… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes adverse events ‐ deaths (RR < 1 denotes lower risk) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical recovery ‐ harmful or hazardous alcohol use (1 to 6 months post intervention) · adult patients with harmful or hazardous alcohol or substance use

Primary health professional‐ and community professional‐led… showed no clear difference in clinical recovery ‐ harmful or hazardous alcohol use (1 to 6 months… compared with enhanced usual care (moderate certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Cannabis use · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of cannabis use (1 to 6 months post intervention) (RR < 1… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) ‐ risk of hazardous or harmful alcohol use · adult patients with harmful or hazardous alcohol or substance use
1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical symptoms ‐ overall risk of harmful or hazardous alcohol and substance use (1 to 6 months post intervention) · adult patients with harmful or hazardous alcohol or substance use
1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Quality of life (1 to 6 months post intervention) · adult patients with harmful or hazardous alcohol or substance use

Primary health professional‐ and community professional‐led… showed no clear difference in quality of life (1 to 6 months post intervention) compared with enhanced usual care (moderate certainty).

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Service utilisation · adults with common mental disorders

It is very uncertain whether lay health worker‐led psychological interventions changes service utilisation (1 to 6 months post intervention) compared with usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Adverse events (1 to 6 months post intervention) ‐ incidence of alcohol‐related consequences ‐ accidents (RR > 1 denotes greater risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes adverse events (1 to 6 months post intervention) ‐ incidence of… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical recovery ‐ harmful or dependent alcohol use (1 to 6 months post intervention) Defined by AUDIT score < 8 (RR > 1 denotes higher likelihood of recovery) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical recovery ‐ harmful or dependent alcohol use (1 to 6 months… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical symptoms ‐ alcohol use (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical symptoms ‐ depression (1 to 6 months post intervention) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical symptoms ‐ depression (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review