Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia
The review found no eligible studies for this question.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adolescents and adults undergoing orthodontic treatment
Low‐level laser therapy (LLLT) showed no clear difference in patient‐reported pain intensity or pain relief (VAS, NRS or… compared with placebo (or no irradiation); GRADE not reported.
5 findings from 1 review
MD -10.63 [-22.33, 1.07]
2 studies · 118 participants
GRADE not reported
MD -6.39 [-8.65, -4.13]
1 study · 58 participants
GRADE not reported
Two further studies (160 participants) used bespoke assessments. Harazaki 1997 (84 participants): slightly lower proportion reporting severe pain in the intervention group, no inferential statistics. Turhani 2006 (76…
2 studies · 160 participants
GRADE not reported
Show 2 more findings
MD -10.76 [-13.80, -7.73]
2 studies · 118 participants
GRADE not reported
MD -20.27 [-24.50, -16.04]
2 studies · 118 participants
Low
Adverse event: tremor · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
It is very uncertain whether antidepressants (trazodone 200 mg/day) changes adverse effects: tremor compared with placebo (very low certainty).
1 finding from 1 review
Reduction of apnoea to less than one episode per hour (polysomnography) · Children with obstructive sleep apnoea (aged 15 years or younger)
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adolescents/teenagers undergoing orthodontic treatment
Experimental chewing adjuncts (bite wafers or chewing gum) showed no clear difference in patient‐reported pain intensity or pain relief (VAS, NRS or… compared with no chewing gum, placebo, or control (no adjunct); GRADE not reported.
5 findings from 1 review
MD -1.39 [-3.24, 0.64]
1 study · 39 participants
GRADE not reported
MD -29.16 [-51.67, -6.65]
1 study · 39 participants
GRADE not reported
MD -15.17 [-32.44, 2.11]
2 studies · 96 participants
GRADE not reported
Show 2 more findings
MD -15.38 [-28.90, -1.86]
2 studies · 96 participants
Very low
Non‐pharmacological interventions for alleviating pain during orthodontic treatment 2016 · Cochrane All outcomes1 day · Bite wafer subgroup (median data, opposite direction)
Otasevic 2006 (84 participants) presented median values only and reported higher median pain in the bite wafer group than the group who avoided chewing at one day (P = 0.006); data not suitable for meta‐analysis.
1 study · 84 participants
GRADE not reported
Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
It is very uncertain whether benzodiazepines (systemic clonazepam 0.5 mg/day) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).
1 finding from 1 review
Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 5, Safety of the intervention up to 3 months: 'All patients in the bleomycin group developed erythema with erosion by the end of the applications, whereas erythema developed in the placebo group. Discomfort was…
1 study
GRADE not reported
Occurrence of postoperative infection - 4 weeks · People requiring retreatment of periapical lesions (failed root canal therapy)
It is very uncertain whether preoperative antibiotic prophylaxis changes occurrence of postoperative infection - 4 weeks compared with placebo (very low certainty).
1 finding from 1 review
QoL · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
Anxiety · Children and adolescents aged up to 17 years having dental treatment (orthodontic treatment, fillings, pulp treatment, or tooth…
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects: exacerbation of symptoms · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
It is very uncertain whether dietary supplements (Catuama herbal compound) changes adverse effects: exacerbation of symptoms compared with placebo (very low certainty).
1 finding from 1 review
Daytime symptom: thirstiness in the morning (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)
Oral appliance or functional orthopaedic appliance showed no clear difference in daytime symptom: thirstiness in the morning (questionnaire) compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Signs and symptoms of atypical swallowing and speech production disturbances · Children with obstructive sleep apnoea (aged 15 years or younger)
The review found no eligible studies for this question.
1 finding from 1 review
Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
Adverse effects of pain treatment · Adolescents and adults undergoing orthodontic treatment
The review found no eligible studies for this question.
1 finding from 1 review
Reduction of apnoea episodes (apnoea-hypopnoea index) · Children with obstructive sleep apnoea (aged 15 years or younger)
It is very uncertain whether oral appliance or functional orthopaedic appliance changes reduction of apnoea episodes (apnoea-hypopnoea index) compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review
Somnolence · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
It is very uncertain whether dietary supplements (Catuama herbal compound) changes adverse effects: drowsiness compared with placebo (very low certainty).
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adolescents and adults undergoing orthodontic treatment
Vibratory stimulation (vibratory adjuncts) showed no clear difference in patient‐reported pain intensity or pain relief (VAS, NRS or… compared with no vibration or placebo vibration; GRADE not reported.
5 findings from 1 review
MD 1.28 [-3.16, 5.71]
3 studies · 154 participants
GRADE not reported
MD -0.52 [-9.41, 8.36]
2 studies · 115 participants
GRADE not reported
Lobre 2015 (high risk of bias): mean overall pain intensity 8.49 mm lower on the VAS during the second month (P = 0.04) and 6.26 mm lower during the fourth month (P = 0.03); no evidence of benefit at month one or month…
2 studies
GRADE not reported
Show 2 more findings