Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,100 questions · 1,164 findings · 107 reviews

No studies found 280 · 24.1%GRADE not reported 159 · 13.7%Very low 292 · 25.1%Low 274 · 23.5%Moderate 113 · 9.7%High 46 · 4%

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Normalcy of diet (mean worst ability to eat, 1 to 4 scale) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (mean worst ability to eat, 1 to 4 scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Granulocyte-colony stimulating factor (G-CSF; pegfilgrastim, single dose) vs Granulocyte-colony stimulating factor (G-CSF; filgrastim, multiple doses)

Normalcy of diet (total parenteral nutrition) · Children receiving bone marrow/stem cell transplantation after conditioning therapy for mixed cancers

Granulocyte-colony stimulating factor (G-CSF; pegfilgrastim, single… showed no clear difference in normalcy of diet (total parenteral nutrition) compared with granulocyte-colony stimulating factor (G-CSF; filgrastim, multiple…; GRADE not reported.

1 finding from 1 review

Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash vs Sucralfate mouthwash

Normalcy of diet (percutaneous endoscopic gastrostomy) · Adults receiving radiotherapy to the head and neck

Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash showed no clear difference in normalcy of diet (percutaneous endoscopic gastrostomy) compared with sucralfate mouthwash; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Normalcy of diet (supplemental nutrition: TPN, PEG, nasogastric tube or IV hydration) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (supplemental nutrition: TPN, PEG, nasogastric tube… compared with placebo; GRADE not reported.

1 finding from 1 review

Targeted mass media intervention vs targeted mass media intervention plus personalised content

Intake meeting target from dietary guidelines, 3 months from baseline · adult, ethnic minority groups: Latino immigrants, elderly Chinese immigrants, self‐described Americans of African heritage

It is very uncertain whether targeted mass media intervention changes intake meeting target from dietary guidelines, 3 months from baseline compared with targeted mass media intervention plus personalised content (very low certainty).

1 finding from 1 review

Targeted mass media intervention vs targeted mass media intervention plus personalised content

Changes in dietary composition, 12 months from baseline · adult, ethnic minority groups: Latino immigrants, elderly Chinese immigrants, self‐described Americans of African heritage
1 finding from 1 review

GM-CSF vs placebo or no treatment

Normalcy of diet (total parenteral nutrition) · Adults with cancer receiving treatment

Granulocyte-macrophage colony-stimulating factor (GM-CSF) showed no clear difference in normalcy of diet (total parenteral nutrition) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

G‐CSF vs placebo or no treatment

Normalcy of diet (percutaneous endoscopic gastrostomy) · Adults with cancer receiving treatment

Granulocyte-colony stimulating factor (G-CSF) showed no clear difference in normalcy of diet (percutaneous endoscopic gastrostomy) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review