Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,655 questions · 1,751 findings · 147 reviews · Pain, Palliative and Supportive Care

No studies found 361 · 20.6%GRADE not reported 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

NSAIDs vs placebo

Patient Global Impression of Change much or very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

It is very uncertain whether non‐steroidal anti‐inflammatory drugs (NSAID) changes PGIC much or very much improved ( compared with placebo (very low certainty).

1 finding from 1 review

Psychological therapies vs controls

Responder rate (achievement of at least 50% reduction in migraine frequency) Higher numbers mean more people responded · adults with migraine

It is very uncertain whether psychological therapies changes responder rate (achievement of at least 50% reduction in migraine… compared with controls (very low certainty).

1 finding from 1 review

Continuous local anaesthetic wound infusion vs placebo

Any serious postoperative adverse event (until hospital discharge) · adults undergoing elective midline laparotomy for colorectal resection

Continuous local anaesthetic wound infusion showed no clear difference in any serious postoperative adverse event (until hospital discharge) compared with placebo (low certainty).

1 finding from 1 review