Parathyroid hormone · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Parathyroid hormone: WMD -196.05 (95% CI -298.43 to -93.66), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
Risk of requiring dialysis · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Risk of requiring dialysis: RR 0.76 (95% CI 0.36 to 1.62), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Parathyroid hormone · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Parathyroid hormone: WMD -49.34 (95% CI -85.70 to -12.97), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Vascular calcification · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Vascular calcification: RR 1.09 (95% CI 0.45 to 2.67), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
All‐cause mortality · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Mortality: RR 1.34 (95% CI 0.34 to 5.24), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Alkaline phosphatase · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Alkaline phosphatase: WMD -27.35 (95% CI -50.69 to -4.01), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Parathyroidectomy · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Parathyroidectomy: RR 0.82 (95% CI 0.05 to 12.47), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Alkaline phosphatase · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Alkaline phosphatase: WMD -21.81 (95% CI -40.39 to 3.22), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Risk of hyperphosphataemia · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Risk of hyperphosphataemia: RR 1.58 (95% CI 0.47 to 5.30), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Bone pain · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Bone pain: RR 0.29 (95% CI 0.03 to 2.63), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
It is very uncertain whether high-dose vitamin D3 supplementation during pregnancy (2400 IU/day… changes caries presence in primary teeth compared with low-dose (standard) vitamin D supplementation as recommended in… (very low certainty).
1 finding from 1 review
Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
The review found no eligible studies for this question.
2 findings from 1 review
Hip Fracture · post‐menopausal women and older people at risk of osteoporotic fractures
Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining new hip fracture (1 year estimate) compared with control or placebo (high certainty).
1 finding from 1 review
Persons sustaining new non‐vertebral fracture (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures
1 finding from 1 review
Fractures: vertebral or deformity · post‐menopausal women and older people at risk of osteoporotic fractures
1 finding from 1 review
New fractures · post‐menopausal women and older people at risk of osteoporotic fractures
Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining any new fracture (1 year estimate) compared with control or placebo (high certainty).
1 finding from 1 review
Apixaban (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review
no estimate extracted
2 studies · 8638 participants
Moderate
no estimate extracted
2 studies · 8638 participants
Moderate
no estimate extracted
2 studies · 8544 participants
High
Rivaroxaban (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review
no estimate extracted
3 studies · 21870 participants
High
no estimate extracted
3 studies · 21870 participants
Moderate
no estimate extracted
3 studies · 21870 participants
High
Dabigatran (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review
no estimate extracted
1 study · 1861 participants
Low
no estimate extracted
1 study · 1861 participants
Low
no estimate extracted
1 study · 1861 participants
Low
Health‐related quality of life (HRQL) · people with asthma
1 finding from 1 review