Findings

What do systematic reviews say?

603 questions · 627 findings · 69 reviews · Pain, Palliative and Supportive Care

No studies found 111 · 17.7%GRADE not reported 27 · 4.3%Very low 191 · 30.5%Low 138 · 22%Moderate 100 · 15.9%High 60 · 9.6%

Rescue free laxation within 4 hours · patients with the management of opioid‐induced constipation in palliative care patients

Methylnaltrexone probably leads to higher rescue free laxation within 4 hours compared with placebo (moderate certainty).

1 finding from 1 review

Laxatives or methylnaltrexone for the management of constipation in palliative care patients 2011 · Cochrane Headline outcomes only
OR 6.95 [3.83, 12.61]
2 studies · 287 participants
Moderate

Rescue free laxation within 24 hours · patients with the management of opioid‐induced constipation in palliative care patients

Methylnaltrexone probably leads to higher rescue free laxation within 24 hours compared with placebo (moderate certainty).

1 finding from 1 review

Laxatives or methylnaltrexone for the management of constipation in palliative care patients 2011 · Cochrane Headline outcomes only
OR 5.42 [3.12, 9.41]
2 studies · 287 participants
Moderate

Fatigue score change

1 finding from 1 review

Drug therapy for the management of cancer‐related fatigue 2010 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 410 participants
High