What do systematic reviews say?

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Biological therapy leads to lower overall survival compared with placebo, best supportive care (BSC) or no treatment (high certainty).

• Salvage systemic therapy for advanced gastric and oesophago‐gastric junction adenocarcinoma 2020 · Cochrane Headline outcomes only
  HR 0.55 [0.41, 0.73]
  3 studies · 781 participants
  High

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Biological therapy probably leads to lower progression‐free survival compared with placebo, best supportive care (BSC) or no treatment (moderate certainty).

• Salvage systemic therapy for advanced gastric and oesophago‐gastric junction adenocarcinoma 2020 · Cochrane Headline outcomes only
  HR 0.33 [0.19, 0.57]
  3 studies · 781 participants
  Moderate

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Biological therapy showed no clear difference in serious adverse events compared with placebo, best supportive care (BSC) or no treatment (low certainty).

• Salvage systemic therapy for advanced gastric and oesophago‐gastric junction adenocarcinoma 2020 · Cochrane Headline outcomes only
  RR 1.14 [0.95, 1.37]
  2 studies · 638 participants
  Low

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Biological therapy may leads to higher tumour response rate compared with placebo, best supportive care (BSC) or no treatment (low certainty).

• Salvage systemic therapy for advanced gastric and oesophago‐gastric junction adenocarcinoma 2020 · Cochrane Headline outcomes only
  RR 5.12 [1.23, 21.27]
  3 studies · 687 participants
  Low

Positional therapy vs continuous positive airway pressure (CPAP)

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Low

Positional therapy vs inactive control

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 101 participants
  Low

Positional therapy vs inactive control

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 101 participants
  Low

Positional therapy vs inactive control

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 86 participants
  Moderate

Positional therapy vs inactive control

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 30 participants
  Low

Positional therapy vs inactive control

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 86 participants
  Very low

Positional therapy vs continuous positive airway pressure (CPAP)

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 33 participants
  Low

Positional therapy vs continuous positive airway pressure (CPAP)

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Moderate

Positional therapy vs continuous positive airway pressure (CPAP)

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  GRADE not reported

Positional therapy vs continuous positive airway pressure (CPAP)

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Low

Positional therapy vs continuous positive airway pressure (CPAP)

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 13 participants
  Low

Positional therapy vs continuous positive airway pressure (CPAP)

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 13 participants
  GRADE not reported

Positional therapy vs inactive control

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 187 participants
  Moderate

Positional therapy vs inactive control

• Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 277 participants
  Low

Puvatherapy vs placebo or no treatment

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 22 participants
  Very low

Puvatherapy vs placebo or no treatment

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found