Findings

What do systematic reviews say?

3,696 questions · 3,815 findings · 855 reviews

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No studies found 573 · 15%GRADE not reported 374 · 9.8%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Late (seven days or more following birth) higher vs lower sodium intake

Neurodevelopmental disability · preterm or low birth weight infants

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Benzodiazepines (systemic clonazepam 0.5 mg/day) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether benzodiazepines (systemic clonazepam 0.5 mg/day) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
short-term (up to 3 months) · systemic clonazepam
MD 0.00 [-1.86, 1.86]
1 study · 20 participants
Very low

Light interventions (5/7): Bright light alone during day vs normal light (530 to 648 lux)

Quality of sleep · Shift workers

1 finding from 1 review

Person‐directed, non‐pharmacological interventions for sleepiness at work and sleep disturbances caused by shift work 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 61 participants
Low

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) vs Colchicine (systemic; 1 mg daily)

Alleviation of oral aphthous ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) led to higher alleviation of oral aphthous ulcers compared with colchicine (systemic; 1 mg daily); GRADE not reported.

1 finding from 1 review

Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
16 weeks
RR 3.3 [1.85, 5.88]
1 study · 92 participants
GRADE not reported

Light interventions (5/7): Bright light alone during day vs dim red light

Total sleep time, next night; · Shift workers

1 finding from 1 review

Person‐directed, non‐pharmacological interventions for sleepiness at work and sleep disturbances caused by shift work 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Low

Light interventions (5/7): Bright light alone during day vs dim red light

Sleep onset latency, next night; · Shift workers

1 finding from 1 review

Person‐directed, non‐pharmacological interventions for sleepiness at work and sleep disturbances caused by shift work 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Low

Early (less than seven days following birth) higher vs lower sodium intake

Mortality Mortality at latest · preterm or low birth weight infants

Early (less than seven days following birth) higher showed no clear difference in mortality (latest time reported up to hospital discharge) compared with lower sodium intake (low certainty).

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
RR 1.02 [0.38, 2.72]
3 studies · 83 participants
Low

Early (less than seven days following birth) higher vs lower sodium intake

Neurodevelopmental disability · preterm or low birth weight infants

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Early (less than seven days following birth) higher vs lower sodium intake

Hyponatraemia (< 130 mmol/L) · preterm or low birth weight infants

Early (less than seven days following birth) higher showed no clear difference in hyponatraemia (< 130 mmol/L) compared with lower sodium intake (low certainty).

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
RR 0.68 [0.4, 1.13]
3 studies · 83 participants
Low

Early (less than seven days following birth) higher vs lower sodium intake

Hypernatraemia (≥ 150 mmol/L) · preterm or low birth weight infants

Early (less than seven days following birth) higher showed no clear difference in hypernatraemia (≥ 150 mmol/L) compared with lower sodium intake (low certainty).

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
RR 1.62 [1, 2.65]
4 studies · 103 participants
Low

Early (less than seven days following birth) higher vs lower sodium intake

Postnatal growth failure · preterm or low birth weight infants

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Early (less than seven days following birth) higher vs lower sodium intake

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether early (less than seven days following birth) higher changes necrotising enterocolitis compared with lower sodium intake (very low certainty).

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
RR 4.6 [0.23, 90.84]
1 study · 46 participants
Very low

Early (less than seven days following birth) higher vs lower sodium intake

Chronic lung disease · preterm or low birth weight infants

1 finding from 1 review

Higher versus lower sodium intake for preterm infants 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Summary of findings: 1.25 mg/day plus rehabilitation vs placebo plus rehabilitation

Function ‐ not measured · rotator cuff disease

The review found no eligible studies for this question.

1 finding from 1 review

Topical glyceryl trinitrate for rotator cuff disease 2009 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: 1.25 mg/day plus rehabilitation vs placebo plus rehabilitation

Harms · rotator cuff disease

The review found no eligible studies for this question.

1 finding from 1 review

Topical glyceryl trinitrate for rotator cuff disease 2009 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: 1.25 mg/day plus rehabilitation vs placebo plus rehabilitation

Headache · rotator cuff disease

Summary of findings: 1.25 mg/day plus rehabilitation showed no clear difference in headache ( compared with placebo plus rehabilitation (low certainty).

1 finding from 1 review

Topical glyceryl trinitrate for rotator cuff disease 2009 · Cochrane Headline outcomes only
RR 1.73 [0.92, 3.24]
1 study · 53 participants
Low

Summary of findings: 1.25 mg/day plus rehabilitation vs placebo plus rehabilitation

Rash · rotator cuff disease

Summary of findings: 1.25 mg/day plus rehabilitation showed no clear difference in rash ( compared with placebo plus rehabilitation (low certainty).

1 finding from 1 review

Topical glyceryl trinitrate for rotator cuff disease 2009 · Cochrane Headline outcomes only
RR 3.12 [0.35, 28.06]
1 study · 53 participants
Low

Summary of findings: 1.25 mg/day plus rehabilitation vs placebo plus rehabilitation

Benefits · rotator cuff disease

The review found no eligible studies for this question.

1 finding from 1 review

Topical glyceryl trinitrate for rotator cuff disease 2009 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: 1.25 mg/day plus rehabilitation vs placebo plus rehabilitation

Pain ‐ not reported1 · rotator cuff disease

The review found no eligible studies for this question.

1 finding from 1 review

Topical glyceryl trinitrate for rotator cuff disease 2009 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: 1.25 mg/day plus rehabilitation vs placebo plus rehabilitation

Symptom free with activities of daily living (patient rated) ( · rotator cuff disease

Summary of findings: 1.25 mg/day plus rehabilitation showed no clear difference in symptom free with activities of daily living (patient rated) ( compared with placebo plus rehabilitation (low certainty).

1 finding from 1 review

Topical glyceryl trinitrate for rotator cuff disease 2009 · Cochrane Headline outcomes only
RR 1.92 [0.92, 4.1]
1 study · 57 participants
Low