Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Negative pressure wound therapy vs standard dressing

Surgical site infection · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy probably leads to lower surgical site infection (proportion of participants in each group… compared with standard dressing (moderate certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Wound dehiscence · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in dehiscence (proportion of participants in each group with wound… compared with standard dressing (moderate certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Seroma (proportion of participants in each group with seroma; · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy showed no clear difference in seroma (proportion of participants in each group with seroma; compared with standard dressing (low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Haematoma (proportion of participants in each group with haematoma; · adult patients with surgical wounds healing by primary closure

It is very uncertain whether negative pressure wound therapy changes haematoma (proportion of participants in each group with haematoma; compared with standard dressing (very low certainty).

1 finding from 1 review

Negative pressure wound therapy vs standard dressing

Skin blisters (proportion of participants in each group with at least one skin blister; · adult patients with surgical wounds healing by primary closure

Negative pressure wound therapy may leads to higher skin blisters (proportion of participants in each group with at… compared with standard dressing (low certainty).

1 finding from 1 review

Comprehensive geriatric assessment (CGA) vs usual care

Serious adverse events (falls) Median · older people at risk of poor health outcomes

It is very uncertain whether comprehensive Geriatric Assessment changes serious adverse events (falls) Median compared with usual care (very low certainty).

1 finding from 1 review

Remote ischaemic preconditioning (RIPC) vs no RIPC

Perioperative mortality · people undergoing elective major vascular surgery

Remote ischaemic preconditioning (RIPC) showed no clear difference in perioperative mortality (within 1 month after operation) compared with no RIPC (moderate certainty).

1 finding from 1 review

Remote ischaemic preconditioning (RIPC) vs no RIPC

Myocardial infarction (0 to 30 days) · people undergoing elective major vascular surgery

Remote ischaemic preconditioning (RIPC) showed no clear difference in myocardial infarction (within 1 month after operation) compared with no RIPC (moderate certainty).

1 finding from 1 review

Remote ischaemic preconditioning (RIPC) vs no RIPC

Renal impairment (within 1 month after operation) · people undergoing elective major vascular surgery

Remote ischaemic preconditioning (RIPC) showed no clear difference in renal impairment (within 1 month after operation) compared with no RIPC (moderate certainty).

1 finding from 1 review