Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

Intervention not reported

DAN score at 30 s after heel lance Range of scale 0‐10 A lower score = less pain (Carbajal 1997) · neonates with heel lance‐associated pain
1 finding from 1 review

Intervention not reported

NFCS Range of scale 0‐10 in term infants 0‐9 in preterm infants A lower score = less pain Grunau 1987 · newborns with heel lance‐associated pain
1 finding from 1 review

Intervention not reported

PIPP 30 s after heel lance (term and preterm infants) Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · newborns with heel lance‐associated pain
1 finding from 1 review

Intervention not reported

PIPP 60 s after heel lance Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · newborns with heel lance‐associated pain
1 finding from 1 review

Topiramate vs placebo

Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder
2 findings from 1 review

Intervention not reported

Improvement of motor function at the end of treatment ‐ upper and lower extremities motor function (FMA) · adults with stroke
1 finding from 1 review

Statins vs placebo

Mean pressure gradient (mmHg) Better indicated by lower scores. · patients with aortic valve stenosis

Statin showed no clear difference in mean pressure gradient (mmHg) Better indicated by lower scores. compared with placebo (low certainty).

1 finding from 1 review