Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

885 questions · 903 findings · 72 reviews

No studies found 106 · 11.7%GRADE not reported 45 · 5%Very low 114 · 12.6%Low 238 · 26.4%Moderate 314 · 34.8%High 86 · 9.5%

Children: formoterol/fluticasone vs regular salmeterol and fluticasone

Non‐fatal serious adverse events · children with chronic asthma

Children: formoterol/fluticasone showed no clear difference in all‐cause non‐fatal serious adverse events compared with salmeterol/fluticasone (low certainty).

1 finding from 1 review

Adults: formoterol/ICS vs salmeterol/ICS

All‐cause mortality ‐ formoterol/mometasone vs salmeterol/fluticasone · adults, chronic asthma: all‐cause mortality

Adults: formoterol/ICS showed no clear difference in all‐cause mortality ‐ formoterol/mometasone vs salmeterol/fluticasone compared with salmeterol/ICS (low certainty).

1 finding from 1 review

Adults: formoterol/ICS vs salmeterol/ICS

All‐cause mortality ‐ formoterol/fluticasone vs salmeterol/fluticasone · adults, chronic asthma: all‐cause mortality

Adults: formoterol/ICS showed no clear difference in all‐cause mortality ‐ formoterol/fluticasone vs salmeterol/fluticasone compared with salmeterol/ICS (low certainty).

1 finding from 1 review

Adults: formoterol/ICS vs salmeterol/ICS

All‐cause non‐fatal serious adverse events ‐ formoterol and budesonide vs salmeterol and fluticasone · adults, chronic asthma: all‐cause mortality

Adults: formoterol/ICS showed no clear difference in all‐cause non‐fatal serious adverse events ‐ formoterol/budesonide… compared with salmeterol/ICS (moderate certainty).

1 finding from 1 review

Adults: formoterol/ICS vs salmeterol/ICS

All‐cause non‐fatal SAE ‐ Adults · adults, chronic asthma: all‐cause mortality

Adults: formoterol/ICS showed no clear difference in all‐cause non‐fatal serious adverse events ‐… compared with salmeterol/ICS (moderate certainty).

1 finding from 1 review

Adults: formoterol/ICS vs salmeterol/ICS

All‐cause non‐fatal serious adverse events ‐ formoterol/mometasone vs salmeterol/fluticasone · adults, chronic asthma: all‐cause mortality

Adults: formoterol/ICS showed no clear difference in all‐cause non‐fatal serious adverse events ‐ formoterol/mometasone… compared with salmeterol/ICS (moderate certainty).

1 finding from 1 review

Adults: formoterol/ICS vs salmeterol/ICS

All‐cause non‐fatal serious adverse events ‐ formoterol/fluticasone vs salmeterol/fluticasone · adults, chronic asthma: all‐cause mortality

Adults: formoterol/ICS showed no clear difference in all‐cause non‐fatal serious adverse events ‐ formoterol/fluticasone… compared with salmeterol/ICS (low certainty).

1 finding from 1 review

Regular formoterol and ICS vs same‐dose ICS

Asthma‐related non‐fatal serious adverse events · adults, chronic asthma: all‐cause mortality

Regular formoterol and ICS showed no clear difference in asthma‐related non‐fatal serious adverse events compared with same‐dose ICS (moderate certainty).

1 finding from 1 review

Regular formoterol and ICS vs same‐dose ICS

Asthma‐related non‐fatal serious adverse events · children and adolescents with chronic asthma

It is very uncertain whether regular formoterol and ICS changes asthma‐related non‐fatal serious adverse events compared with same‐dose ICS (very low certainty).

1 finding from 1 review

Effects of different delivery devices on growth in children with persistent asthma: hydrofluoroalkane‐metered dose inhaler beclomethasone vs beclomethasone

Linear growth velocity (cm/year) · children up to 18 years of age with persistent asthma

Effects of different delivery devices on growth in children with… showed no clear difference in linear growth velocity (cm/year) compared with chlorofluorocarbon‐metered dose inhaler beclomethasone (low certainty).

1 finding from 1 review

Effects of different delivery devices on growth in children with persistent asthma: Easyhaler‐budesonide vs Turbuhaler‐budesonide

Change in height · children up to 18 years of age with persistent asthma

Effects of different delivery devices on growth in children with… may leads to higher change in height (cm) over a period of time compared with turbuhaler‐budesonide (low certainty).

1 finding from 1 review